U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Schip1 Schwannomin interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34393, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Schip1provided by FlyBase
Official Full Name
Schwannomin interacting protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0032221
Locus tag
Dmel_CG5375
See related
AllianceGenome:FB:FBgn0032221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5375; Dmel\CG5375
Summary
Involved in negative regulation of growth; positive regulation of hippo signaling; and positive regulation of protein serine/threonine kinase activity. Located in adherens junction and apical plasma membrane. Is expressed in eye disc and wing disc. Orthologous to human IQCJ-SCHIP1 (IQCJ-SCHIP1 readthrough) and SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Schip1 in Genome Data Viewer
Location:
31D8-31D9; 2-41 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10328200..10331116, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10328200..10331116, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonucleoside diphosphate reductase large subunit Neighboring gene Cytochrome c oxidase assembly factor 10 Neighboring gene GATAd

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling. Chung HL, et al. Dev Cell, 2016 Mar 7. PMID 26954546
  2. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
  4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
  5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Schip1 directly links Ex to Hpo signaling by recruiting Tao-1
    Title: Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
schwannomin interacting protein 1
Names
CG5375-PB
CG5375-PC
Schip1 ortholog
Schip1-PB
Schip1-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10328200..10331116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347808.1 → NP_001334735.1  schwannomin interacting protein 1, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1W5PX37

  2. NM_001103669.2 → NP_001097139.1  schwannomin interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DYY6
    Conserved Domains (1) summary
    pfam10148
    Location:374 → 602
    SCHIP-1; Schwannomin-interacting protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1W5PX37 A0A1W5PX37
A8DYY6.1 A8DYY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools