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idha-1 putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 172655, updated on 9-Dec-2024

Summary

Official Symbol
idha-1
Official Full Name
putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Primary source
WormBase:WBGene00009664
Locus tag
CELE_F43G9.1
See related
AllianceGenome:WB:WBGene00009664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable isocitrate dehydrogenase (NAD+) activity. Involved in protein folding. Located in mitochondrion. Is expressed in several structures, including hypodermis; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See idha-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (8606549..8608631, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein Neighboring gene DFDF domain-containing protein Neighboring gene Vesicle transport protein Neighboring gene ncRNA Neighboring gene LysM domain-containing protein Neighboring gene PWWP domain-containing protein

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isocitrate dehydrogenase (NAD+) activity  
enables isocitrate dehydrogenase (NAD+) activity  
enables metal ion binding  
enables oxidoreductase activity  
Process Evidence Code Pubs
involved_in isocitrate metabolic process  
involved_in protein folding PubMed 
involved_in tricarboxylic acid cycle  
involved_in tricarboxylic acid cycle  
Component Evidence Code Pubs
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion  

General protein information

Preferred Names
putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
NP_492330.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8606549..8608631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059929.6NP_492330.2  putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492330.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93714
    Conserved Domains (1) summary
    cl00445
    Location:22354
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
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