icl-1 Malate synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: icl-1
Official Full Name: Malate synthase
Primary source: WormBase:WBGene00001564
Locus tag: CELE_C05E4.9
See related: AllianceGenome:WB:WBGene00001564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable isocitrate lyase activity and malate synthase activity. Involved in determination of adult lifespan. Located in mitochondrion. Is expressed in hypodermal cell; intestine; and pharynx. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See icl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (724332..728004, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response.
Title: The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H24O09.a (e-PCR)
- UniSTS:322589

H24O09.e (e-PCR)
- UniSTS:322591

H24O09.f (e-PCR)
- UniSTS:322592

C05E4.9 (e-PCR)
- UniSTS:308479

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables isocitrate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate lyase activity	IEA Inferred from Electronic Annotation more info
enables isocitrate lyase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables malate synthase activity	IEA Inferred from Electronic Annotation more info
enables malate synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in glyoxylate cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: Malate synthase

NP_001021367.1

Confirmed by transcript evidence

NP_503306.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

724332..728004 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026196.7 → NP_001021367.1 Malate synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10663

Conserved Domains (2) summary

PRK15063
Location:15 → 431

PRK15063; isocitrate lyase; Provisional

cd00727
Location:456 → 860

malate_synt_A; Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to ...
NM_070905.7 → NP_503306.1 Malate synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503306.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17353, Q10663, Q8IA71

Conserved Domains (2) summary

PRK15063
Location:15 → 431

PRK15063; isocitrate lyase; Provisional

cd00727
Location:456 → 964

malate_synt_A; Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to ...