mdh-2 Malate dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mdh-2
Official Full Name: Malate dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00003162
Locus tag: CELE_F20H11.3
See related: AllianceGenome:WB:WBGene00003162
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in malate metabolic process. Located in mitochondrion. Is expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mdh-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (6606544..6608106, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.
Title: Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20H11.3 (e-PCR)
- UniSTS:309857

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables L-malate dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malate metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Malate dehydrogenase, mitochondrial

NP_498457.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6606544..6608106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066056.7 → NP_498457.1 Malate dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498457.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02640

Conserved Domains (2) summary

cd01337
Location:30 → 338

MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

PLN00106
Location:15 → 333

PLN00106; malate dehydrogenase