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MESK2 Misexpression suppressor of KSR 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37451, updated on 9-Dec-2024

Summary

Official Symbol
MESK2provided by FlyBase
Official Full Name
Misexpression suppressor of KSR 2provided by FlyBase
Primary source
FLYBASE:FBgn0043070
Locus tag
Dmel_CG15669
See related
AllianceGenome:FB:FBgn0043070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH12032; BcDNA:LD27504; BcDNA:RH10174; CG15668; CG15669; Dmel\CG15669; l(2)01467; mesk2; Mesk2
Summary
Enables serine hydrolase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to several human genes including NDRG1 (N-myc downstream regulated 1); NDRG2 (NDRG family member 2); and NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See MESK2 in Genome Data Viewer
Location:
57E8-57E9; 2-95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21502097..21517241)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17389602..17404746)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit C-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in signal transduction  
Component Evidence Code Pubs
is_active_in cytoplasm  

General protein information

Preferred Names
misexpression suppressor of KSR 2
Names
CG15669-PA
CG15669-PB
CG15669-PC
CG15669-PD
CG15669-PE
CG15669-PF
CG15669-PI
CG15669-PJ
CG15669-PK
MESK2-PA
MESK2-PB
MESK2-PC
MESK2-PD
MESK2-PE
MESK2-PF
MESK2-PI
MESK2-PJ
MESK2-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21502097..21517241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206192.2 → NP_995914.1  misexpression suppressor of KSR 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GU50
    Conserved Domains (2) summary
    COG0596
    Location:57 → 334
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:51 → 337
    Abhydrolase; alpha/beta hydrolases
  2. NM_206193.2 → NP_995915.1  misexpression suppressor of KSR 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGI1
    Conserved Domains (2) summary
    COG0596
    Location:40 → 317
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:34 → 320
    Abhydrolase; alpha/beta hydrolases
  3. NM_166454.2 → NP_726076.1  misexpression suppressor of KSR 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Related
    FBpp0088650
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases
  4. NM_206190.2 → NP_995912.1  misexpression suppressor of KSR 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases
  5. NM_079080.3 → NP_523804.3  misexpression suppressor of KSR 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523804.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRK7
    Related
    FBpp0088652
    Conserved Domains (2) summary
    COG0596
    Location:57 → 334
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:51 → 337
    Abhydrolase; alpha/beta hydrolases
  6. NM_166455.2 → NP_726077.1  misexpression suppressor of KSR 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726077.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q9I7V7
    Related
    FBpp0088649
    Conserved Domains (1) summary
    cl21494
    Location:133 → 421
    Abhydrolase; alpha/beta hydrolases
  7. NM_166456.3 → NP_726078.1  misexpression suppressor of KSR 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q9I7V6
    Related
    FBpp0088651
    Conserved Domains (1) summary
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases
  8. NM_206194.2 → NP_995916.1  misexpression suppressor of KSR 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVN1, Q8IHC7
    Conserved Domains (1) summary
    cl21494
    Location:105 → 391
    Abhydrolase; alpha/beta hydrolases
  9. NM_206191.2 → NP_995913.1  misexpression suppressor of KSR 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases
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