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Teratoma with malignant transformation

MedGen UID:
87256
•Concept ID:
C0334523
•
Neoplastic Process
Synonyms: Dermoid cyst with malignant transformation; Dermoid Cyst with Malignant Transformation; dermoid cyst with malignant transformation; Dermoid cyst with secondary tumor; Teratoma with Malignant Transformation; teratoma with malignant transformation; Teratoma with Somatic-Type Malignancy; TMT
SNOMED CT: Teratoma with malignant transformation (88334008); Dermoid cyst with malignant transformation (88334008); Dermoid cyst with secondary tumor (88334008)
 
Monarch Initiative: MONDO:0006444

Definition

A teratoma which is characterized by morphologic transformation to malignancy and an aggressive clinical course. The malignant component most often is sarcomatous or carcinomatous. [from NCI]

Professional guidelines

PubMed

Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal.
Necchi A, Colecchia M, Nicolai N, Piva L, Catanzaro M, Biasoni D, Torelli T, Stagni S, Paolini B, Milani A, Salvioni R
BJU Int 2011 Apr;107(7):1088-94. Epub 2010 Sep 24 doi: 10.1111/j.1464-410X.2010.09705.x. PMID: 20868391
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Recent clinical studies

Etiology

Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma.
Wang X, Li W, Kong Y, Liu X, Cui Z
J Int Med Res 2021 Feb;49(2):300060520981549. doi: 10.1177/0300060520981549. PMID: 33530815Free PMC Article
Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Late relapse of germ cell tumors.
Oldenburg J, Wahlqvist R, Fosså SD
World J Urol 2009 Aug;27(4):493-500. Epub 2009 Apr 17 doi: 10.1007/s00345-009-0411-3. PMID: 19373473

Diagnosis

Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Retroperitoneal Teratoma With Malignant Transformation.
Lee KF, Lo EYJ, Cheung SYS
Clin Gastroenterol Hepatol 2023 Oct;21(11):A23-A24. Epub 2023 Apr 8 doi: 10.1016/j.cgh.2023.03.030. PMID: 37037261
Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Ovarian mature cystic teratoma with malignant transformation: two case reports.
Tehranian A, Ghahghaei-Nezamabadi A, Seifollahi A, Kasraei S, Dehghani-Nejad H, Maleki-Hajiagha A
J Med Case Rep 2021 Jan 27;15(1):23. doi: 10.1186/s13256-020-02594-4. PMID: 33499917Free PMC Article
Teratoma with malignant transformation: report of three cases and review of the literature.
Cabral FC, Krajewski KM, Rosenthal MH, Hirsch MS, Howard SA
Clin Imaging 2014 Sep-Oct;38(5):589-93. Epub 2014 Apr 28 doi: 10.1016/j.clinimag.2014.04.011. PMID: 24908364

Therapy

Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Adenocarcinoma With Breast/Adnexal and Upper Gastrointestinal Differentiation Arising in an Ovarian Mature Cystic Teratoma: A Case Report and Review of the Literature.
Wheeler L, Westhoff GL, O'Keefe MC, Kong CS, Karam A
Int J Gynecol Pathol 2016 Jan;35(1):72-7. doi: 10.1097/PGP.0000000000000218. PMID: 26352552
Late relapse of germ cell tumors.
Oldenburg J, Lorch A, Fosså SD
Hematol Oncol Clin North Am 2011 Jun;25(3):615-26, x. doi: 10.1016/j.hoc.2011.03.006. PMID: 21570613
Third-line chemotherapy and novel agents for metastatic germ cell tumors.
Veenstra CM, Vaughn DJ
Hematol Oncol Clin North Am 2011 Jun;25(3):577-91, ix. Epub 2011 Apr 22 doi: 10.1016/j.hoc.2011.03.005. PMID: 21570610
Prognostic features of teratomas with malignant transformation: a clinicopathological study of 21 cases.
Comiter CV, Kibel AS, Richie JP, Nucci MR, Renshaw AA
J Urol 1998 Mar;159(3):859-63. PMID: 9474169

Prognosis

Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Ovarian mature cystic teratoma with malignant transformation: two case reports.
Tehranian A, Ghahghaei-Nezamabadi A, Seifollahi A, Kasraei S, Dehghani-Nejad H, Maleki-Hajiagha A
J Med Case Rep 2021 Jan 27;15(1):23. doi: 10.1186/s13256-020-02594-4. PMID: 33499917Free PMC Article
Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Teratoma with malignant transformation: report of three cases and review of the literature.
Cabral FC, Krajewski KM, Rosenthal MH, Hirsch MS, Howard SA
Clin Imaging 2014 Sep-Oct;38(5):589-93. Epub 2014 Apr 28 doi: 10.1016/j.clinimag.2014.04.011. PMID: 24908364
Late relapse of germ cell tumors.
Oldenburg J, Wahlqvist R, Fosså SD
World J Urol 2009 Aug;27(4):493-500. Epub 2009 Apr 17 doi: 10.1007/s00345-009-0411-3. PMID: 19373473

Clinical prediction guides

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
CT findings of mature cystic teratoma with malignant transformation: comparison with mature cystic teratoma.
Park SB, Cho KS, Kim JK
Clin Imaging 2011 Jul-Aug;35(4):294-300. doi: 10.1016/j.clinimag.2010.08.016. PMID: 21724123
Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96.
Biskup W, Calaminus G, Schneider DT, Leuschner I, Göbel U
Klin Padiatr 2006 Nov-Dec;218(6):303-8. doi: 10.1055/s-2006-942272. PMID: 17080331
Chemotherapy for teratoma with malignant transformation.
Donadio AC, Motzer RJ, Bajorin DF, Kantoff PW, Sheinfeld J, Houldsworth J, Chaganti RS, Bosl GJ
J Clin Oncol 2003 Dec 1;21(23):4285-91. doi: 10.1200/JCO.2003.01.019. PMID: 14645417

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