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Abnormality of the menstrual cycle

MedGen UID:: 893088
•Concept ID:: C4025888
•: Finding

Synonym:	Menstrual abnormalities

HPO:	HP:0000140

Definition

An abnormality of the ovulation cycle. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of the menstrual cycle

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the genitourinary system
    - Abnormality of the genital system
      - Abnormality of reproductive system physiology
        Abnormal female reproductive system physiology
        Abnormality of the menstrual cycle
        Amenorrhea
        Primary amenorrhea
        Secondary amenorrhea
        Irregular menstruation
        Dysmenorrhea
        Menometrorrhagia
        Metrorrhagia
        Oligomenorrhea
        Polymenorrhea

Conditions with this feature

46,XY sex reversal 1

MedGen UID:: 412662
•Concept ID:: C2748896
•: Disease or Syndrome

Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the SRY gene, encoding sex-determining region Y protein.

See: Condition Record

Oocyte maturation defect 8

MedGen UID:: 1776094
•Concept ID:: C5436597
•: Disease or Syndrome

Oocyte/zygote/embryo maturation arrest-8 (OZEMA8) is characterized by female infertility due to failure of the fertilized ovum to undergo zygotic cleavage (Zheng et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.

See: Condition Record

Oocyte maturation defect 9

MedGen UID:: 1724427
•Concept ID:: C5436599
•: Disease or Syndrome

Oocyte/zygote/embryo maturation arrest-9 (OZEMA9) is characterized by female infertility due to oocyte meiotic arrest at metaphase I in most patients. Abnormal zygotic cleavage has also been observed (Zhang et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.

See: Condition Record

46,XY sex reversal 1

Oocyte maturation defect 8

Oocyte maturation defect 9

Professional guidelines

PubMed

Hypothyroidism: Diagnosis and Evidence-Based Treatment.

Davis MG, Phillippi JC
J Midwifery Womens Health 2022 May;67(3):394-397. Epub 2022 Apr 5 doi: 10.1111/jmwh.13358. PMID: 35384263

Diagnosis and treatment of luteal phase deficiency: a committee opinion.

Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855

See all (115)

Recent clinical studies

Etiology

Amenorrhea.

Heiman DL
Prim Care 2009 Mar;36(1):1-17, vii. doi: 10.1016/j.pop.2008.10.005. PMID: 19231599

Antipsychotic-induced hyperprolactinemia.

Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797

Dysmenorrhea in adolescents.

Harel Z
Ann N Y Acad Sci 2008;1135:185-95. doi: 10.1196/annals.1429.007. PMID: 18574224

Women and diabetes.

Lunt H
Diabet Med 1996 Dec;13(12):1009-16. doi: 10.1002/(SICI)1096-9136(199612)13:12<1009::AID-DIA281>3.0.CO;2-U. PMID: 8973881

Adolescent menstrual irregularity.

Mansfield MJ, Emans SJ
J Reprod Med 1984 Jun;29(6):399-410. PMID: 6379175

See all (1189)

Diagnosis

A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593 Free PMC Article

Polycystic ovary syndrome.

Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ
Lancet Diabetes Endocrinol 2022 Sep;10(9):668-680. Epub 2022 Aug 4 doi: 10.1016/S2213-8587(22)00163-2. PMID: 35934017

Approach to Abnormal Uterine Bleeding in Adolescents.

Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387 Free PMC Article

Premenstrual syndrome: A mini review.

Ryu A, Kim TH
Maturitas 2015 Dec;82(4):436-40. Epub 2015 Aug 28 doi: 10.1016/j.maturitas.2015.08.010. PMID: 26351143

Menstrual disorders.

Deligeoroglou E, Creatsas G
Endocr Dev 2012;22:160-170. Epub 2012 Jul 25 doi: 10.1159/000331697. PMID: 22846527

See all (810)

Therapy

A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593 Free PMC Article

Premenstrual syndrome and premenstrual dysphoric disorder in adolescents.

Itriyeva K
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101187. Epub 2022 May 6 doi: 10.1016/j.cppeds.2022.101187. PMID: 35534402

The Treatment of Dysmenorrhea.

Ryan SA
Pediatr Clin North Am 2017 Apr;64(2):331-342. doi: 10.1016/j.pcl.2016.11.004. PMID: 28292449

Premenstrual syndrome: A mini review.

Ryu A, Kim TH
Maturitas 2015 Dec;82(4):436-40. Epub 2015 Aug 28 doi: 10.1016/j.maturitas.2015.08.010. PMID: 26351143

Antipsychotic-induced hyperprolactinemia.

Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797

See all (780)

Prognosis

Diagnosis and treatment of luteal phase deficiency: a committee opinion.

PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation.

Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Atik RB, Bloemenkamp KW, Brady R, Briley A, Cavallaro R, Cheong YC, Chu J, Eapen A, Essex H, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Parrott S, Ross JA, Sharpe L, Stewart J, Trépel D, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R
Health Technol Assess 2016 May;20(41):1-92. doi: 10.3310/hta20410. PMID: 27225013 Free PMC Article

Ovarian incidentaloma.

Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456

Women and diabetes.

Lunt H
Diabet Med 1996 Dec;13(12):1009-16. doi: 10.1002/(SICI)1096-9136(199612)13:12<1009::AID-DIA281>3.0.CO;2-U. PMID: 8973881

See all (349)

Clinical prediction guides

The menstrual distress questionnaire (MEDI-Q): reliability and validity of the English version.

Cassioli E, Rossi E, Melani G, Faldi M, Rellini AH, Wyatt RB, Oester C, Vannuccini S, Petraglia F, Ricca V, Castellini G
Gynecol Endocrinol 2023 Jun 19;39(1):2227275. doi: 10.1080/09513590.2023.2227275. PMID: 37356456

Menstrual hygiene practices and associated factors among Indian adolescent girls: a meta-analysis.

Majeed J, Sharma P, Ajmera P, Dalal K
Reprod Health 2022 Jun 23;19(1):148. doi: 10.1186/s12978-022-01453-3. PMID: 35739585 Free PMC Article

Diagnosis and treatment of luteal phase deficiency: a committee opinion.

Approach to Abnormal Uterine Bleeding in Adolescents.

Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387 Free PMC Article

Ovarian incidentaloma.

Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456

See all (713)

Recent systematic reviews

Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.

Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SM
Pan Afr Med J 2023;44:134. Epub 2023 Mar 16 doi: 10.11604/pamj.2023.44.134.32404. PMID: 37333786 Free PMC Article

Cesarean scar defects and abnormal uterine bleeding: a systematic review and meta-analysis.

Murji A, Sanders AP, Monteiro I, Haiderbhai S, Matelski J, Walsh C, Abbott JA, Munro MG, Maheux-Lacroix S; International Federation of Gynecology and Obstetrics (FIGO) Committee on Menstrual Disorders and Related Health Impacts
Fertil Steril 2022 Oct;118(4):758-766. Epub 2022 Aug 17 doi: 10.1016/j.fertnstert.2022.06.031. PMID: 35985862

Menstrual hygiene practices and associated factors among Indian adolescent girls: a meta-analysis.

Majeed J, Sharma P, Ajmera P, Dalal K
Reprod Health 2022 Jun 23;19(1):148. doi: 10.1186/s12978-022-01453-3. PMID: 35739585 Free PMC Article

Menstrual cycle-related fluctuations in oxytocin concentrations: A systematic review and meta-analysis.

Engel S, Klusmann H, Ditzen B, Knaevelsrud C, Schumacher S
Front Neuroendocrinol 2019 Jan;52:144-155. Epub 2018 Nov 17 doi: 10.1016/j.yfrne.2018.11.002. PMID: 30458185

Antifibrinolytics for heavy menstrual bleeding.

Bryant-Smith AC, Lethaby A, Farquhar C, Hickey M
Cochrane Database Syst Rev 2018 Apr 15;4(4):CD000249. doi: 10.1002/14651858.CD000249.pub2. PMID: 29656433 Free PMC Article

See all (33)

MedGen

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Abnormality of the menstrual cycle

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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