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Dermatitis, atopic, 8(ATOD8)

MedGen UID:
462113
•Concept ID:
C3150763
•
Disease or Syndrome
Synonym: DERMATITIS, ATOPIC, SEVERITY OF
 
Monarch Initiative: MONDO:0013294
OMIM®: 613518

Definition

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 4q22.1. [from MONDO]

Professional guidelines

PubMed

Review of an established UK home phototherapy service 1998-2011: improving access to a cost-effective treatment for chronic skin disease.
Cameron H, Yule S, Dawe RS, Ibbotson SH, Moseley H, Ferguson J
Public Health 2014 Apr;128(4):317-24. Epub 2014 Apr 13 doi: 10.1016/j.puhe.2014.01.011. PMID: 24726005
Food anaphylaxis in schools: evaluation of the management plan and the efficiency of the emergency kit.
Moneret-Vautrin DA, Kanny G, Morisset M, Flabbee J, Guénard L, Beaudouin E, Parisot L
Allergy 2001 Nov;56(11):1071-6. doi: 10.1034/j.1398-9995.2001.00047.x. PMID: 11703221

Recent clinical studies

Etiology

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Atopic dermatitis displays stable and dynamic skin transcriptome signatures.
Möbus L, Rodriguez E, Harder I, Stölzl D, Boraczynski N, Gerdes S, Kleinheinz A, Abraham S, Heratizadeh A, Handrick C, Haufe E, Werfel T, Schmitt J, Weidinger S; TREATgermany study group
J Allergy Clin Immunol 2021 Jan;147(1):213-223. Epub 2020 Jun 29 doi: 10.1016/j.jaci.2020.06.012. PMID: 32615169
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article
Atopic dermatitis: global epidemiology and risk factors.
Nutten S
Ann Nutr Metab 2015;66 Suppl 1:8-16. Epub 2015 Apr 24 doi: 10.1159/000370220. PMID: 25925336

Diagnosis

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies.
Papp K, Szepietowski JC, Kircik L, Toth D, Eichenfield LF, Leung DYM, Forman SB, Venturanza ME, Sun K, Kuligowski ME, Simpson EL
J Am Acad Dermatol 2021 Oct;85(4):863-872. Epub 2021 May 4 doi: 10.1016/j.jaad.2021.04.085. PMID: 33957195
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article
Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection.
Fishbein AB, Silverberg JI, Wilson EJ, Ong PY
J Allergy Clin Immunol Pract 2020 Jan;8(1):91-101. Epub 2019 Aug 29 doi: 10.1016/j.jaip.2019.06.044. PMID: 31474543Free PMC Article

Therapy

Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies.
Papp K, Szepietowski JC, Kircik L, Toth D, Eichenfield LF, Leung DYM, Forman SB, Venturanza ME, Sun K, Kuligowski ME, Simpson EL
J Am Acad Dermatol 2021 Oct;85(4):863-872. Epub 2021 May 4 doi: 10.1016/j.jaad.2021.04.085. PMID: 33957195
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD
J Allergy Clin Immunol 2019 Jan;143(1):155-172. Epub 2018 Sep 5 doi: 10.1016/j.jaci.2018.08.022. PMID: 30194992

Prognosis

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Molecular Mechanisms of Atopic Dermatitis Pathogenesis.
Sroka-Tomaszewska J, Trzeciak M
Int J Mol Sci 2021 Apr 16;22(8) doi: 10.3390/ijms22084130. PMID: 33923629Free PMC Article
The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017.
Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SM, Dellavalle RP, Flohr C
Br J Dermatol 2021 Feb;184(2):304-309. Epub 2020 Nov 29 doi: 10.1111/bjd.19580. PMID: 33006135
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article

Clinical prediction guides

Phytotherapy in paediatric skin disorders - A systematic literature review.
Kloter E, Albanese F, Schweighoffer R, Wolf U
Complement Ther Med 2023 Jun;74:102942. Epub 2023 Mar 21 doi: 10.1016/j.ctim.2023.102942. PMID: 36958415
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.
Guttman-Yassky E, Renert-Yuval Y, Bares J, Chima M, Hawkes JE, Gilleaudeau P, Sullivan-Whalen M, Singer GK, Garcet S, Pavel AB, Lebwohl MG, Krueger JG
Allergy 2022 Mar;77(3):897-906. Epub 2021 Sep 6 doi: 10.1111/all.15071. PMID: 34460948Free PMC Article
Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies.
Papp K, Szepietowski JC, Kircik L, Toth D, Eichenfield LF, Leung DYM, Forman SB, Venturanza ME, Sun K, Kuligowski ME, Simpson EL
J Am Acad Dermatol 2021 Oct;85(4):863-872. Epub 2021 May 4 doi: 10.1016/j.jaad.2021.04.085. PMID: 33957195
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article

Recent systematic reviews

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Allergen immunotherapy for atopic dermatitis: Systematic review and meta-analysis of benefits and harms.
Yepes-Nuñez JJ, Guyatt GH, Gómez-Escobar LG, Pérez-Herrera LC, Chu AWL, Ceccaci R, Acosta-Madiedo AS, Wen A, Moreno-López S, MacDonald M, Barrios M, Chu X, Islam N, Gao Y, Wong MM, Couban R, Garcia E, Chapman E, Oykhman P, Chen L, Winders T, Asiniwasis RN, Boguniewicz M, De Benedetto A, Ellison K, Frazier WT, Greenhawt M, Huynh J, Kim E, LeBovidge J, Lind ML, Lio P, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel J, Wang J, Wheeler KE, Schneider L, Chu DK
J Allergy Clin Immunol 2023 Jan;151(1):147-158. Epub 2022 Sep 30 doi: 10.1016/j.jaci.2022.09.020. PMID: 36191689
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA
J Drugs Dermatol 2019 Jan 1;18(1):9-16. PMID: 30681787
Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence.
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821

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