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Dermatitis, atopic, 5(ATOD5)

MedGen UID:
381292
•Concept ID:
C1853900
•
Disease or Syndrome
Synonym: Dermatitis, Atopic, 5
 
Monarch Initiative: MONDO:0011608
OMIM®: 605844

Definition

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 13q12-q14. [from MONDO]

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617

Recent clinical studies

Etiology

Treat-to-Target in Atopic Dermatitis.
Vestergaard C, Skovsgaard C, Johansen C, Deleuran M, Thyssen JP
Am J Clin Dermatol 2024 Jan;25(1):91-98. Epub 2023 Dec 11 doi: 10.1007/s40257-023-00827-y. PMID: 38079107
Comorbidities of atopic dermatitis-what does the evidence say?
Thyssen JP, Halling AS, Schmid-Grendelmeier P, Guttman-Yassky E, Silverberg JI
J Allergy Clin Immunol 2023 May;151(5):1155-1162. Epub 2023 Jan 6 doi: 10.1016/j.jaci.2022.12.002. PMID: 36621338
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Eczema.
Sohn A, Frankel A, Patel RV, Goldenberg G
Mt Sinai J Med 2011 Sep-Oct;78(5):730-9. doi: 10.1002/msj.20289. PMID: 21913202

Diagnosis

Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Novel insights into atopic dermatitis.
Schuler CF 4th, Billi AC, Maverakis E, Tsoi LC, Gudjonsson JE
J Allergy Clin Immunol 2023 May;151(5):1145-1154. Epub 2022 Nov 22 doi: 10.1016/j.jaci.2022.10.023. PMID: 36428114Free PMC Article
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Atopic dermatitis.
Heath CR, Usatine RP
J Fam Pract 2021 Jun;70(5):252. doi: 10.12788/jfp.0211. PMID: 34410918
Eczema.
Sohn A, Frankel A, Patel RV, Goldenberg G
Mt Sinai J Med 2011 Sep-Oct;78(5):730-9. doi: 10.1002/msj.20289. PMID: 21913202

Therapy

Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu DK, Chu AWL, Rayner DG, Guyatt GH, Yepes-Nuñez JJ, Gomez-Escobar L, Pérez-Herrera LC, Díaz Martinez JP, Brignardello-Petersen R, Sadeghirad B, Wong MM, Ceccacci R, Zhao IX, Basmaji J, MacDonald M, Chu X, Islam N, Gao Y, Izcovich A, Asiniwasis RN, Boguniewicz M, De Benedetto A, Capozza K, Chen L, Ellison K, Frazier WT, Greenhawt M, Huynh J, LeBovidge J, Lio PA, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Smith Begolka W, Wang J, Wheeler KE, Gardner DD, Schneider L
J Allergy Clin Immunol 2023 Dec;152(6):1493-1519. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.030. PMID: 37678572
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies.
Mandlik DS, Mandlik SK
Immunopharmacol Immunotoxicol 2021 Apr;43(2):105-125. Epub 2021 Feb 28 doi: 10.1080/08923973.2021.1889583. PMID: 33645388
Atopic dermatitis in children.
Strathie Page S, Weston S, Loh R
Aust Fam Physician 2016 May;45(5):293-6. PMID: 27166464

Prognosis

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials.
Simpson EL, Papp KA, Blauvelt A, Chu CY, Hong HC, Katoh N, Calimlim BM, Thyssen JP, Chiou AS, Bissonnette R, Stein Gold LF, Wegzyn C, Hu X, Liu M, Liu J, Tenorio AR, Chu AD, Guttman-Yassky E
JAMA Dermatol 2022 Apr 1;158(4):404-413. doi: 10.1001/jamadermatol.2022.0029. PMID: 35262646Free PMC Article
Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.
Guttman-Yassky E, Renert-Yuval Y, Bares J, Chima M, Hawkes JE, Gilleaudeau P, Sullivan-Whalen M, Singer GK, Garcet S, Pavel AB, Lebwohl MG, Krueger JG
Allergy 2022 Mar;77(3):897-906. Epub 2021 Sep 6 doi: 10.1111/all.15071. PMID: 34460948Free PMC Article

Clinical prediction guides

Treat-to-Target in Atopic Dermatitis.
Vestergaard C, Skovsgaard C, Johansen C, Deleuran M, Thyssen JP
Am J Clin Dermatol 2024 Jan;25(1):91-98. Epub 2023 Dec 11 doi: 10.1007/s40257-023-00827-y. PMID: 38079107
Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus.
Kabashima K, Matsumura T, Komazaki H, Kawashima M; Nemolizumab-JP01 Study Group
N Engl J Med 2020 Jul 9;383(2):141-150. doi: 10.1056/NEJMoa1917006. PMID: 32640132
Epidemiology of adult atopic dermatitis.
Sacotte R, Silverberg JI
Clin Dermatol 2018 Sep-Oct;36(5):595-605. Epub 2018 May 31 doi: 10.1016/j.clindermatol.2018.05.007. PMID: 30217272
Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis.
Dermatology 1993;186(1):23-31. doi: 10.1159/000247298. PMID: 8435513

Recent systematic reviews

Abrocitinib, tralokinumab and upadacitinib for treating moderate-to-severe atopic dermatitis.
Edwards SJ, Karner C, Jhita T, Barton S, Marceniuk G, Yiu ZZN, Wittmann M
Health Technol Assess 2024 Jan;28(4):1-113. doi: 10.3310/LEXB9006. PMID: 38343072Free PMC Article
Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu DK, Chu AWL, Rayner DG, Guyatt GH, Yepes-Nuñez JJ, Gomez-Escobar L, Pérez-Herrera LC, Díaz Martinez JP, Brignardello-Petersen R, Sadeghirad B, Wong MM, Ceccacci R, Zhao IX, Basmaji J, MacDonald M, Chu X, Islam N, Gao Y, Izcovich A, Asiniwasis RN, Boguniewicz M, De Benedetto A, Capozza K, Chen L, Ellison K, Frazier WT, Greenhawt M, Huynh J, LeBovidge J, Lio PA, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Smith Begolka W, Wang J, Wheeler KE, Gardner DD, Schneider L
J Allergy Clin Immunol 2023 Dec;152(6):1493-1519. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.030. PMID: 37678572
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article

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