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Multiple sclerosis, susceptibility to, 2(MS2)

MedGen UID:
436444
Concept ID:
C2675478
Finding
Synonym: MS2
 
Monarch Initiative: MONDO:0012956
OMIM®: 612594

Term Hierarchy

Professional guidelines

PubMed

Mizuguchi M, Ohsawa M, Kashii H, Sato A
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136677. PMID: 34206526Free PMC Article
Huynh JL, Casaccia P
Lancet Neurol 2013 Feb;12(2):195-206. doi: 10.1016/S1474-4422(12)70309-5. PMID: 23332363Free PMC Article
Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H
Genet Med 2007 Feb;9(2):88-100. doi: 10.1097/gim.0b013e31803068c7. PMID: 17304050

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS
JAMA Neurol 2019 Dec 1;76(12):1474-1483. doi: 10.1001/jamaneurol.2019.2399. PMID: 31403674Free PMC Article
Tremlett H, Waubant E
Mult Scler 2018 Jan;24(1):64-68. doi: 10.1177/1352458517737369. PMID: 29307301
Files DK, Jausurawong T, Katrajian R, Danoff R
Prim Care 2015 Jun;42(2):159-75. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.007. PMID: 25979578
International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Martinelli Boneschi F, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BA, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PI, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SF, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung HP, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppä V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero IL, Mihalova T, Montalban X, Mottershead J, Myhr KM, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux JD, Rodegher M, Roesner S, Rubio JP, Rückert IM, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PM, Smestad C, Sørensen PS, Søndergaard HB, Stankovich J, Strange RC, Sulonen AM, Sundqvist E, Syvänen AC, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CN, Wichmann HE, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P, Compston A
Nature 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature10251. PMID: 21833088Free PMC Article

Diagnosis

Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H
Front Immunol 2022;13:872126. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.872126. PMID: 36211369Free PMC Article
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS
JAMA Neurol 2019 Dec 1;76(12):1474-1483. doi: 10.1001/jamaneurol.2019.2399. PMID: 31403674Free PMC Article
Cook L
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.DMIH2-0010-2015. PMID: 27726799
Files DK, Jausurawong T, Katrajian R, Danoff R
Prim Care 2015 Jun;42(2):159-75. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.007. PMID: 25979578
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592

Therapy

International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H
Front Immunol 2022;13:872126. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.872126. PMID: 36211369Free PMC Article
Cryan JF, O'Riordan KJ, Sandhu K, Peterson V, Dinan TG
Lancet Neurol 2020 Feb;19(2):179-194. Epub 2019 Nov 18 doi: 10.1016/S1474-4422(19)30356-4. PMID: 31753762
Files DK, Jausurawong T, Katrajian R, Danoff R
Prim Care 2015 Jun;42(2):159-75. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.007. PMID: 25979578

Prognosis

Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M
EBioMedicine 2023 Aug;94:104701. Epub 2023 Jul 10 doi: 10.1016/j.ebiom.2023.104701. PMID: 37437310Free PMC Article
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS
JAMA Neurol 2019 Dec 1;76(12):1474-1483. doi: 10.1001/jamaneurol.2019.2399. PMID: 31403674Free PMC Article
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592
Miller E
Adv Exp Med Biol 2012;724:222-38. doi: 10.1007/978-1-4614-0653-2_17. PMID: 22411246

Clinical prediction guides

Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M
EBioMedicine 2023 Aug;94:104701. Epub 2023 Jul 10 doi: 10.1016/j.ebiom.2023.104701. PMID: 37437310Free PMC Article
International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Calvi A, Clarke MA, Prados F, Chard D, Ciccarelli O, Alberich M, Pareto D, Rodríguez Barranco M, Sastre-Garriga J, Tur C, Rovira A, Barkhof F
Mult Scler 2023 Mar;29(3):352-362. Epub 2022 Dec 14 doi: 10.1177/13524585221141964. PMID: 36515487Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717

Recent systematic reviews

Voon CC, Wiltgen T, Wiestler B, Schlaeger S, Mühlau M
Neuroimage Clin 2024;42:103598. Epub 2024 Mar 25 doi: 10.1016/j.nicl.2024.103598. PMID: 38582068Free PMC Article
De Silvestri A, Capittini C, Mallucci G, Bergamaschi R, Rebuffi C, Pasi A, Martinetti M, Tinelli C
Dis Markers 2019;2019:1409069. Epub 2019 Nov 6 doi: 10.1155/2019/1409069. PMID: 31781296Free PMC Article
Zhang YJ, Zhang L, Chen SY, Yang GJ, Huang XL, Duan Y, Yang LJ, Ye DQ, Wang J
Neurol Sci 2018 Feb;39(2):225-234. Epub 2017 Nov 6 doi: 10.1007/s10072-017-3175-3. PMID: 29110148
Jaruvongvanich V, Sanguankeo A, Jaruvongvanich S, Upala S
Mult Scler Relat Disord 2016 May;7:92-7. Epub 2016 Mar 30 doi: 10.1016/j.msard.2016.03.013. PMID: 27237767
Benamer HT, Ahmed ES, Al-Din AS, Grosset DG
J Neurol Sci 2009 Mar 15;278(1-2):1-4. Epub 2009 Jan 9 doi: 10.1016/j.jns.2008.12.001. PMID: 19135686

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

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