U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pediatric multiple sclerosis

MedGen UID:
1799994
•Concept ID:
C5568571
•
Disease or Syndrome
Synonym: Pediatric MS
SNOMED CT: Pediatric multiple sclerosis (1186728004)
 
Monarch Initiative: MONDO:0018784
Orphanet: ORPHA477738

Definition

A rare multiple sclerosis (MS) variant with characteristics of the onset of one or multiple episodes of clinical central nervous system (CNS) symptoms consistent with acquired CNS demyelination, with radiologically proven dissemination of inflammatory lesions in space and time, following exclusion of other disorders before the age of 18 years old. Patients present a predominantly relapsing-remitting course with the first attack usually consisting of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis and monofocal or polyfocal neurological deficits. A high burden of T2-hyperintense lesions on initial MRI, primarily of the supratentorial region and/or of the cervical spinal cord has been reported. [from SNOMEDCT_US]

Professional guidelines

PubMed

Pediatric multiple sclerosis - current status of epidemiology, diagnosis and treatment.
Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Treatment of pediatric multiple sclerosis.
Kornek B
Neuropediatrics 2013 Dec;44(6):309-13. Epub 2013 Nov 7 doi: 10.1055/s-0033-1359308. PMID: 24203855
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions.
Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E; International Pediatric Multiple Sclerosis Study Group
Mult Scler 2013 Sep;19(10):1261-7. Epub 2013 Apr 9 doi: 10.1177/1352458513484547. PMID: 23572237

Recent clinical studies

Etiology

Ageing and multiple sclerosis.
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care.
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Pediatric multiple sclerosis.
Yeshokumar AK, Narula S, Banwell B
Curr Opin Neurol 2017 Jun;30(3):216-221. doi: 10.1097/WCO.0000000000000452. PMID: 28323645
Pediatric multiple sclerosis.
Bigi S, Banwell B
J Child Neurol 2012 Nov;27(11):1378-83. Epub 2012 Aug 21 doi: 10.1177/0883073812452784. PMID: 22914372

Diagnosis

Pediatric Multiple Sclerosis.
Kornbluh AB, Kahn I
Semin Pediatr Neurol 2023 Jul;46:101054. Epub 2023 May 11 doi: 10.1016/j.spen.2023.101054. PMID: 37451754
Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care.
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Pediatric multiple sclerosis - current status of epidemiology, diagnosis and treatment.
Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Pediatric multiple sclerosis.
Yeshokumar AK, Narula S, Banwell B
Curr Opin Neurol 2017 Jun;30(3):216-221. doi: 10.1097/WCO.0000000000000452. PMID: 28323645

Therapy

Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care.
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Pediatric Multiple Sclerosis: A Review.
Langille MM, Rutatangwa A, Francisco C
Adv Pediatr 2019 Aug;66:209-229. Epub 2019 Apr 20 doi: 10.1016/j.yapd.2019.03.003. PMID: 31230695
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Pediatric multiple sclerosis.
Banwell BL
Handb Clin Neurol 2013;112:1263-74. doi: 10.1016/B978-0-444-52910-7.00049-0. PMID: 23622337
Pediatric multiple sclerosis.
Yeh EA, Chitnis T, Krupp L, Ness J, Chabas D, Kuntz N, Waubant E; US Network of Pediatric Multiple Sclerosis Centers of Excellence
Nat Rev Neurol 2009 Nov;5(11):621-31. Epub 2009 Oct 13 doi: 10.1038/nrneurol.2009.158. PMID: 19826402

Prognosis

Pediatric Multiple Sclerosis.
Kornbluh AB, Kahn I
Semin Pediatr Neurol 2023 Jul;46:101054. Epub 2023 May 11 doi: 10.1016/j.spen.2023.101054. PMID: 37451754
Ageing and multiple sclerosis.
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Pediatric multiple sclerosis - current status of epidemiology, diagnosis and treatment.
Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Pediatric multiple sclerosis.
Yeshokumar AK, Narula S, Banwell B
Curr Opin Neurol 2017 Jun;30(3):216-221. doi: 10.1097/WCO.0000000000000452. PMID: 28323645

Clinical prediction guides

Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Pediatric Multiple Sclerosis: an Update.
Otallah S, Banwell B
Curr Neurol Neurosci Rep 2018 Sep 18;18(11):76. doi: 10.1007/s11910-018-0886-7. PMID: 30229541
Pediatric multiple sclerosis: Conventional first-line treatment and general management.
Ghezzi A, Amato MP, Makhani N, Shreiner T, Gärtner J, Tenembaum S
Neurology 2016 Aug 30;87(9 Suppl 2):S97-S102. doi: 10.1212/WNL.0000000000002823. PMID: 27572869
Pediatric multiple sclerosis: pathobiological, clinical, and magnetic resonance imaging features.
Verhey LH, Shroff M, Banwell B
Neuroimaging Clin N Am 2013 May;23(2):227-43. Epub 2013 Jan 21 doi: 10.1016/j.nic.2012.12.004. PMID: 23608687
Multiple sclerosis-related fatigue.
MacAllister WS, Krupp LB
Phys Med Rehabil Clin N Am 2005 May;16(2):483-502. doi: 10.1016/j.pmr.2005.01.014. PMID: 15893683

Recent systematic reviews

Anti-CD20 therapies for pediatric-onset multiple sclerosis: A systematic review.
Etemadifar M, Nouri H, Sedaghat N, Ramezani A, Kargaran PK, Salari M, Kaveyee H
Mult Scler Relat Disord 2024 Nov;91:105849. Epub 2024 Aug 31 doi: 10.1016/j.msard.2024.105849. PMID: 39243503
Serum levels of neurofilament light chains in pediatric multiple sclerosis: a systematic review and meta-analysis.
Niculae AŞ, Niculae LE, Văcăraş C, Văcăraş V
J Neurol 2023 Oct;270(10):4753-4762. Epub 2023 Jul 2 doi: 10.1007/s00415-023-11841-9. PMID: 37394516
Quality of life measures in pediatric multiple sclerosis: a systematic review and meta-analysis.
Ow N, Mozafarinia M, Mayo NE
Dev Med Child Neurol 2021 Sep;63(9):1051-1058. Epub 2021 Mar 26 doi: 10.1111/dmcn.14870. PMID: 33769574
Epidemiology of pediatric multiple sclerosis: A systematic literature review and meta-analysis.
Yan K, Balijepalli C, Desai K, Gullapalli L, Druyts E
Mult Scler Relat Disord 2020 Sep;44:102260. Epub 2020 Jun 4 doi: 10.1016/j.msard.2020.102260. PMID: 32540746
The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data.
Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R, Serra A, Di Mauro P, Cocuzza S, Falsaperla R
Hum Vaccin Immunother 2015;11(12):2749-63. doi: 10.1080/21645515.2015.1061161. PMID: 26266339Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...