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Multiple sclerosis, susceptibility to, 3(MS3)

MedGen UID:
390807
Concept ID:
C2675477
Finding
Synonym: MS3
 
Monarch Initiative: MONDO:0012957
OMIM®: 612595

Definition

Multiple sclerosis-3 (MS3) is a chronic inflammatory disease of the central nervous system (CNS) characterized by multifocal demyelination (summary by Kallio et al., 2009). For a discussion of genetic heterogeneity of multiple sclerosis, see MS1 (126200). [from OMIM]

Term Hierarchy

Professional guidelines

PubMed

Kreft KL, Uzochukwu E, Loveless S, Willis M, Wynford-Thomas R, Harding KE, Holmans P, Lawton M, Tallantyre EC, Robertson NP
Ann Neurol 2024 Mar;95(3):459-470. Epub 2023 Dec 9 doi: 10.1002/ana.26831. PMID: 37974536
Timasheva Y, Nasibullin TR, Tuktarova IA, Erdman VV, Galiullin TR, Zaplakhova OV, Bakhtiiarova KZ
Gene 2022 Jan 30;809:146008. Epub 2021 Oct 14 doi: 10.1016/j.gene.2021.146008. PMID: 34656742
Borson-Chazot F, Cardot-Bauters C, Mirallie É, Pattou F; French Endocrine Society
Ann Endocrinol (Paris) 2013 Jul;74(3):200-2. Epub 2013 Jun 13 doi: 10.1016/j.ando.2013.05.006. PMID: 23769271

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Hemond CC, Reich DS, Dundamadappa SK
AJR Am J Roentgenol 2022 Jul;219(1):120-131. Epub 2021 Dec 1 doi: 10.2214/AJR.21.26777. PMID: 34851712Free PMC Article
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS
JAMA Neurol 2019 Dec 1;76(12):1474-1483. doi: 10.1001/jamaneurol.2019.2399. PMID: 31403674Free PMC Article
Poser CM, Brinar VV
Clin Neurol Neurosurg 2002 Jul;104(3):165-7. doi: 10.1016/s0303-8467(02)00032-x. PMID: 12127648

Diagnosis

Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H
Front Immunol 2022;13:872126. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.872126. PMID: 36211369Free PMC Article
Mirzalieva O, Juncker M, Schwartzenburg J, Desai S
Cells 2022 Feb 4;11(3) doi: 10.3390/cells11030538. PMID: 35159348Free PMC Article
Haller S, Haacke EM, Thurnher MM, Barkhof F
Radiology 2021 Apr;299(1):3-26. Epub 2021 Feb 23 doi: 10.1148/radiol.2021203071. PMID: 33620291
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Axisa PP, Hafler DA
Curr Opin Neurol 2016 Jun;29(3):345-53. doi: 10.1097/WCO.0000000000000319. PMID: 27058221Free PMC Article

Therapy

International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H
Front Immunol 2022;13:872126. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.872126. PMID: 36211369Free PMC Article
Axisa PP, Hafler DA
Curr Opin Neurol 2016 Jun;29(3):345-53. doi: 10.1097/WCO.0000000000000319. PMID: 27058221Free PMC Article
Darlington C
Curr Opin Investig Drugs 2002 Jun;3(6):911-4. PMID: 12137412

Prognosis

Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M
EBioMedicine 2023 Aug;94:104701. Epub 2023 Jul 10 doi: 10.1016/j.ebiom.2023.104701. PMID: 37437310Free PMC Article
Mirzalieva O, Juncker M, Schwartzenburg J, Desai S
Cells 2022 Feb 4;11(3) doi: 10.3390/cells11030538. PMID: 35159348Free PMC Article
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS
JAMA Neurol 2019 Dec 1;76(12):1474-1483. doi: 10.1001/jamaneurol.2019.2399. PMID: 31403674Free PMC Article
Miller E
Adv Exp Med Biol 2012;724:222-38. doi: 10.1007/978-1-4614-0653-2_17. PMID: 22411246
Poser CM, Brinar VV
Clin Neurol Neurosurg 2002 Jul;104(3):165-7. doi: 10.1016/s0303-8467(02)00032-x. PMID: 12127648

Clinical prediction guides

Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M
EBioMedicine 2023 Aug;94:104701. Epub 2023 Jul 10 doi: 10.1016/j.ebiom.2023.104701. PMID: 37437310Free PMC Article
International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Calvi A, Clarke MA, Prados F, Chard D, Ciccarelli O, Alberich M, Pareto D, Rodríguez Barranco M, Sastre-Garriga J, Tur C, Rovira A, Barkhof F
Mult Scler 2023 Mar;29(3):352-362. Epub 2022 Dec 14 doi: 10.1177/13524585221141964. PMID: 36515487Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Hong X, Wang X, Rang X, Yin X, Zhang X, Wang R, Wang D, Zhao T, Fu J
Front Immunol 2022;13:857014. Epub 2022 Mar 9 doi: 10.3389/fimmu.2022.857014. PMID: 35356004Free PMC Article

Recent systematic reviews

Ng Kee Kwong KC, Mollison D, Meijboom R, York EN, Kampaite A, Thrippleton MJ, Chandran S, Waldman AD
PLoS One 2021;16(9):e0256845. Epub 2021 Sep 8 doi: 10.1371/journal.pone.0256845. PMID: 34495999Free PMC Article
Mohammadi A, Azarnezhad A, Khanbabaei H, Izadpanah E, Abdollahzadeh R, Barreto GE, Sahebkar A
Steroids 2020 Jun;158:108615. Epub 2020 Feb 22 doi: 10.1016/j.steroids.2020.108615. PMID: 32097613
Zhou SL, Tan CC, Hou XH, Cao XP, Tan L, Yu JT
J Alzheimers Dis 2019;68(3):1171-1184. doi: 10.3233/JAD-181038. PMID: 30883352
Zhao S, Wang J, Liu Y, Luo L, Zhu Z, Li E, Zhao Z
J Sex Med 2018 Dec;15(12):1716-1727. Epub 2018 Nov 2 doi: 10.1016/j.jsxm.2018.09.016. PMID: 30393105
Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I
Lancet Neurol 2015 Mar;14(3):263-73. Epub 2015 Feb 4 doi: 10.1016/S1474-4422(14)70267-4. PMID: 25662901

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

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