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Tumorigenesis

MedGen UID:
3302
Concept ID:
C0007621
Neoplastic Process
Synonyms: Cell Neoplastic Transformation; Cell Neoplastic Transformations; Cell Transformation, Neoplastic; Cell Transformations, Neoplastic; Neoplastic Cell Transformation; Neoplastic Cell Transformations; Neoplastic Transformation, Cell; Neoplastic Transformations, Cell; Transformation, Cell Neoplastic; Transformation, Neoplastic Cell; Transformation, Tumorigenic; Transformations, Cell Neoplastic; Transformations, Neoplastic Cell; Transformations, Tumorigenic; Tumorigenic Transformation; Tumorigenic Transformations

Definition

A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation. [from NCI]

Professional guidelines

PubMed

Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Jansz N, Faulkner GJ
Genome Biol 2021 May 10;22(1):147. doi: 10.1186/s13059-021-02357-4. PMID: 33971937Free PMC Article
Miranda Furtado CL, Dos Santos Luciano MC, Silva Santos RD, Furtado GP, Moraes MO, Pessoa C
Epigenetics 2019 Dec;14(12):1164-1176. Epub 2019 Jul 13 doi: 10.1080/15592294.2019.1640546. PMID: 31282279Free PMC Article

Recent clinical studies

Etiology

Xu X, Wang J, Xu L, Li P, Jiang P
J Clin Invest 2024 Jan 9;134(4) doi: 10.1172/JCI171788. PMID: 38194288Free PMC Article
Chen R, Zou J, Zhong X, Li J, Kang R, Tang D
Cancer Lett 2024 Jan 28;581:216494. Epub 2023 Nov 24 doi: 10.1016/j.canlet.2023.216494. PMID: 38007142
Eldesouki S, Samara KA, Qadri R, Obaideen AA, Otour AH, Habbal O, Bm Ahmed S
Clin Chim Acta 2022 Jun 1;531:283-290. Epub 2022 Apr 26 doi: 10.1016/j.cca.2022.04.993. PMID: 35483442
Cai J, Sun L, Gonzalez FJ
Cell Host Microbe 2022 Mar 9;30(3):289-300. doi: 10.1016/j.chom.2022.02.004. PMID: 35271802Free PMC Article
Yang J, Wei H, Zhou Y, Szeto CH, Li C, Lin Y, Coker OO, Lau HCH, Chan AWH, Sung JJY, Yu J
Gastroenterology 2022 Jan;162(1):135-149.e2. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.041. PMID: 34461052

Diagnosis

Orange ST, Leslie J, Ross M, Mann DA, Wackerhage H
Trends Endocrinol Metab 2023 Nov;34(11):749-763. Epub 2023 Aug 24 doi: 10.1016/j.tem.2023.08.001. PMID: 37633799
Wong CC, Yu J
Nat Rev Clin Oncol 2023 Jul;20(7):429-452. Epub 2023 May 11 doi: 10.1038/s41571-023-00766-x. PMID: 37169888
Kamali Zonouzi S, Pezeshki PS, Razi S, Rezaei N
Clin Transl Oncol 2022 May;24(5):757-769. Epub 2021 Nov 28 doi: 10.1007/s12094-021-02734-2. PMID: 34839457
Sulli G, Lam MTY, Panda S
Trends Cancer 2019 Aug;5(8):475-494. Epub 2019 Aug 3 doi: 10.1016/j.trecan.2019.07.002. PMID: 31421905Free PMC Article
Weksberg R, Shuman C, Beckwith JB
Eur J Hum Genet 2010 Jan;18(1):8-14. doi: 10.1038/ejhg.2009.106. PMID: 19550435Free PMC Article

Therapy

Fassl A, Geng Y, Sicinski P
Science 2022 Jan 14;375(6577):eabc1495. doi: 10.1126/science.abc1495. PMID: 35025636Free PMC Article
Tamura R
Int J Mol Sci 2021 May 29;22(11) doi: 10.3390/ijms22115850. PMID: 34072574Free PMC Article
Yuan J, Dong X, Yap J, Hu J
J Hematol Oncol 2020 Aug 17;13(1):113. doi: 10.1186/s13045-020-00949-4. PMID: 32807225Free PMC Article
Zhou L, Jiang Y, Luo Q, Li L, Jia L
Mol Cancer 2019 Apr 3;18(1):77. doi: 10.1186/s12943-019-0979-1. PMID: 30943988Free PMC Article
Tadesse S, Caldon EC, Tilley W, Wang S
J Med Chem 2019 May 9;62(9):4233-4251. Epub 2018 Dec 20 doi: 10.1021/acs.jmedchem.8b01469. PMID: 30543440

Prognosis

Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Liu T, Zhang X, Du L, Wang Y, Liu X, Tian H, Wang L, Li P, Zhao Y, Duan W, Xie Y, Sun Z, Wang C
Mol Cancer 2019 Mar 19;18(1):43. doi: 10.1186/s12943-019-0981-7. PMID: 30890168Free PMC Article
Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL
CA Cancer J Clin 2018 Jul;68(4):284-296. Epub 2018 May 29 doi: 10.3322/caac.21456. PMID: 29809280Free PMC Article
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Li R, Baack Kukreja JE, Kamat AM
Urol Clin North Am 2018 Feb;45(1):91-99. doi: 10.1016/j.ucl.2017.09.010. PMID: 29169454

Clinical prediction guides

Feng ZH, Liang YP, Cen JJ, Yao HH, Lin HS, Li JY, Liang H, Wang Z, Deng Q, Cao JZ, Huang Y, Wei JH, Luo JH, Chen W, Chen ZH
J Transl Med 2022 Oct 29;20(1):492. doi: 10.1186/s12967-022-03711-1. PMID: 36309694Free PMC Article
Wang X, Ma L, Pei X, Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP, Chen HZ
Brief Bioinform 2022 May 13;23(3) doi: 10.1093/bib/bbac118. PMID: 35419596Free PMC Article
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article
Liu X, Wang J, Chen L
Cancer Lett 2013 Nov 1;340(2):270-6. Epub 2012 Nov 12 doi: 10.1016/j.canlet.2012.11.002. PMID: 23153794

Recent systematic reviews

Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article
Bouleftour W, Guillot A, Magne N
Mol Cancer Ther 2022 Apr 1;21(4):493-501. doi: 10.1158/1535-7163.MCT-21-0846. PMID: 35131876
Zhang Y, Qian J, Gu C, Yang Y
Signal Transduct Target Ther 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. PMID: 33623018Free PMC Article
Li W, He P, Huang Y, Li YF, Lu J, Li M, Kurihara H, Luo Z, Meng T, Onishi M, Ma C, Jiang L, Hu Y, Gong Q, Zhu D, Xu Y, Liu R, Liu L, Yi C, Zhu Y, Ma N, Okamoto K, Xie Z, Liu J, He RR, Feng D
Theranostics 2021;11(1):222-256. Epub 2021 Jan 1 doi: 10.7150/thno.49860. PMID: 33391472Free PMC Article
Braidy N, Liu Y
Exp Gerontol 2020 Apr;132:110831. Epub 2020 Jan 7 doi: 10.1016/j.exger.2020.110831. PMID: 31917996

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