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Tumor Promotion

MedGen UID:
274320
•Concept ID:
C1519689
•
Neoplastic Process

Definition

The second step in two-stage carcinogenesis: the conversion of an initiated (premalignant) cell to malignancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Promotion

Professional guidelines

PubMed

miR-429 as biomarker for diagnosis, treatment and prognosis of cancers and its potential action mechanisms: A systematic literature review.
Guo CM, Liu SQ, Sun MZ
Neoplasma 2020 Mar;67(2):215-228. Epub 2019 Dec 23 doi: 10.4149/neo_2019_190401N282. PMID: 31884798
Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health.
Clergé A, Le Goff J, Lopez C, Ledauphin J, Delépée R
Crit Rev Toxicol 2019 Apr;49(4):302-328. Epub 2019 Sep 12 doi: 10.1080/10408444.2019.1605333. PMID: 31512557
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment.
McClain RM
Prog Clin Biol Res 1995;391:325-36. PMID: 8532725

Recent clinical studies

Etiology

ROS in cancer therapy: the bright side of the moon.
Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, Castoria G, Migliaccio A
Exp Mol Med 2020 Feb;52(2):192-203. Epub 2020 Feb 14 doi: 10.1038/s12276-020-0384-2. PMID: 32060354Free PMC Article
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Safety Aspects of the Use of Quercetin as a Dietary Supplement.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A
Mol Nutr Food Res 2018 Jan;62(1) Epub 2017 Dec 19 doi: 10.1002/mnfr.201700447. PMID: 29127724
Antiangiogenics and Hypoxic Response: Role of Fatty Acid Synthase Inhibitors.
Bueno MJ, Sanchez J, Colomer R, Quintela-Fandino M
Curr Drug Targets 2016;17(15):1735-1746. doi: 10.2174/1389450117666160502151857. PMID: 27138758
The carcinogenicity of ciclosporin.
Ryffel B
Toxicology 1992;73(1):1-22. doi: 10.1016/0300-483x(92)90166-c. PMID: 1589877

Diagnosis

Targeting the cGAS-STING Pathway Inhibits Peripheral T-cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy.
Lu X, Wang S, Hua X, Chen X, Zhan M, Hu Q, Cao L, Wu Z, Zhang W, Zuo X, Gui R, Fan L, Li J, Shi W, Jin H
Adv Sci (Weinh) 2024 Mar;11(10):e2306092. Epub 2023 Dec 25 doi: 10.1002/advs.202306092. PMID: 38145335Free PMC Article
Pan-cancer scRNA-seq analysis reveals immunological and diagnostic significance of the peripheral blood mononuclear cells.
Zhang Y, Zhou X, Zhong Y, Chen X, Li Z, Li R, Qin P, Wang S, Yin J, Liu S, Jiang M, Yu Q, Hou Y, Liu S, Wu L
Hum Mol Genet 2024 Feb 1;33(4):342-354. doi: 10.1093/hmg/ddad187. PMID: 37944069
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.
Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Retroperitoneal mucinous cystadenoma.
Subramony C, Habibpour S, Hashimoto LA
Arch Pathol Lab Med 2001 May;125(5):691-4. doi: 10.5858/2001-125-0691-RMC. PMID: 11300948

Therapy

Safety Aspects of the Use of Quercetin as a Dietary Supplement.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A
Mol Nutr Food Res 2018 Jan;62(1) Epub 2017 Dec 19 doi: 10.1002/mnfr.201700447. PMID: 29127724
Antiangiogenics and Hypoxic Response: Role of Fatty Acid Synthase Inhibitors.
Bueno MJ, Sanchez J, Colomer R, Quintela-Fandino M
Curr Drug Targets 2016;17(15):1735-1746. doi: 10.2174/1389450117666160502151857. PMID: 27138758
Cyclooxygenase-2 and gastric cancer.
Thiel A, Mrena J, Ristimäki A
Cancer Metastasis Rev 2011 Dec;30(3-4):387-95. doi: 10.1007/s10555-011-9312-1. PMID: 22002749
Antioxidant and anti-inflammatory properties of curcumin.
Menon VP, Sudheer AR
Adv Exp Med Biol 2007;595:105-25. doi: 10.1007/978-0-387-46401-5_3. PMID: 17569207
Final report on the safety assessment of BHT(1).
Lanigan RS, Yamarik TA
Int J Toxicol 2002;21 Suppl 2:19-94. doi: 10.1080/10915810290096513. PMID: 12396675

Prognosis

Role of long pentraxin PTX3 in cancer.
Li D, Hao Z, Nan Y, Chen Y
Clin Exp Med 2023 Dec;23(8):4401-4411. Epub 2023 Jul 12 doi: 10.1007/s10238-023-01137-7. PMID: 37438568
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis.
Yang H, Zhang Q, Xu M, Wang L, Chen X, Feng Y, Li Y, Zhang X, Cui W, Jia X
Mol Cancer 2020 Feb 27;19(1):41. doi: 10.1186/s12943-020-01165-x. PMID: 32103760Free PMC Article
Final report on the safety assessment of BHT(1).
Lanigan RS, Yamarik TA
Int J Toxicol 2002;21 Suppl 2:19-94. doi: 10.1080/10915810290096513. PMID: 12396675

Clinical prediction guides

Lung cancer associated with combustion particles and fine particulate matter (PM(2.5)) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR).
Holme JA, Vondráček J, Machala M, Lagadic-Gossmann D, Vogel CFA, Le Ferrec E, Sparfel L, Øvrevik J
Biochem Pharmacol 2023 Oct;216:115801. Epub 2023 Sep 9 doi: 10.1016/j.bcp.2023.115801. PMID: 37696458Free PMC Article
Role of long pentraxin PTX3 in cancer.
Li D, Hao Z, Nan Y, Chen Y
Clin Exp Med 2023 Dec;23(8):4401-4411. Epub 2023 Jul 12 doi: 10.1007/s10238-023-01137-7. PMID: 37438568
Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis.
Yang H, Zhang Q, Xu M, Wang L, Chen X, Feng Y, Li Y, Zhang X, Cui W, Jia X
Mol Cancer 2020 Feb 27;19(1):41. doi: 10.1186/s12943-020-01165-x. PMID: 32103760Free PMC Article
Final report on the safety assessment of BHT(1).
Lanigan RS, Yamarik TA
Int J Toxicol 2002;21 Suppl 2:19-94. doi: 10.1080/10915810290096513. PMID: 12396675

Recent systematic reviews

The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review.
Kandathil SA, Akhondi A, Kadletz-Wanke L, Heiduschka G, Engedal N, Brkic FF
J Cancer Res Clin Oncol 2024 Jan 31;150(2):56. doi: 10.1007/s00432-023-05514-3. PMID: 38291202Free PMC Article
Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge.
Hung YC, Pan TL, Hu WL
Oxid Med Cell Longev 2016;2016:5293284. Epub 2016 Aug 4 doi: 10.1155/2016/5293284. PMID: 27579153Free PMC Article
Statins in the chemoprevention of colorectal cancer in established animal models of sporadic and colitis-associated cancer.
Pikoulis E, Margonis GA, Angelou A, Zografos GC, Antoniou E
Eur J Cancer Prev 2016 Mar;25(2):102-8. doi: 10.1097/CEJ.0000000000000152. PMID: 25768976
Association between growth hormone therapy and mortality, cancer and cardiovascular risk: systematic review and meta-analysis.
Deodati A, Ferroli BB, Cianfarani S
Growth Horm IGF Res 2014 Aug;24(4):105-11. Epub 2014 Apr 13 doi: 10.1016/j.ghir.2014.02.001. PMID: 24818783
Systematic review of wireless phone use and brain cancer and other head tumors.
Repacholi MH, Lerchl A, Röösli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, d'Inzeo G, Elliott P, Frei P, Heinrich S, Lagroye I, Lahkola A, McCormick DL, Thomas S, Vecchia P
Bioelectromagnetics 2012 Apr;33(3):187-206. Epub 2011 Oct 21 doi: 10.1002/bem.20716. PMID: 22021071

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