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Lung neuroendocrine neoplasm

MedGen UID:
277303
•Concept ID:
C1334452
•
Neoplastic Process
Synonyms: Bronchial neuroendocrine tumor; lung NET; Lung Neuroendocrine Neoplasm; lung neuroendocrine neoplasm; lung neuroendocrine tumor; lung neuroendocrine tumor, well differentiated, low or intermediate grade; lung neuroendocrine tumour; Neuroendocrine neoplasm of lung; Neuroendocrine Neoplasm of Lung; neuroendocrine neoplasm of lung; Neuroendocrine Neoplasm of the Lung; neuroendocrine neoplasm of the lung; Pulmonary Neuroendocrine Neoplasm; pulmonary neuroendocrine neoplasm; pulmonary neuroendocrine tumor; pulmonary neuroendocrine tumour
SNOMED CT: Neuroendocrine neoplasm of lung (707594002); Bronchial neuroendocrine tumor (707594002)
 
Monarch Initiative: MONDO:0005454

Definition

A neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma. [from NCI]

Professional guidelines

PubMed

Role of Bone Metastases in Lung Neuroendocrine Neoplasms: Clinical Presentation, Treatment and Impact on Prognosis.
Modica R, Benevento E, Altieri B, Minotta R, Liccardi A, Cannavale G, Di Iasi G, Colao A
Int J Mol Sci 2024 Aug 17;25(16) doi: 10.3390/ijms25168957. PMID: 39201642Free PMC Article

Recent clinical studies

Etiology

Role of Bone Metastases in Lung Neuroendocrine Neoplasms: Clinical Presentation, Treatment and Impact on Prognosis.
Modica R, Benevento E, Altieri B, Minotta R, Liccardi A, Cannavale G, Di Iasi G, Colao A
Int J Mol Sci 2024 Aug 17;25(16) doi: 10.3390/ijms25168957. PMID: 39201642Free PMC Article
Updates on lung neuroendocrine neoplasm classification.
Vocino Trucco G, Righi L, Volante M, Papotti M
Histopathology 2024 Jan;84(1):67-85. Epub 2023 Oct 4 doi: 10.1111/his.15058. PMID: 37794655
Serum tumor markers for detection of bone metastases in patients with lung neuroendocrine neoplasms".
Rosiek V, Wójcik-Giertuga M, Kos-Kudła B
Cancer Treat Res Commun 2022;31:100533. Epub 2022 Feb 15 doi: 10.1016/j.ctarc.2022.100533. PMID: 35202905
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

Diagnosis

Updates on lung neuroendocrine neoplasm classification.
Vocino Trucco G, Righi L, Volante M, Papotti M
Histopathology 2024 Jan;84(1):67-85. Epub 2023 Oct 4 doi: 10.1111/his.15058. PMID: 37794655
The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.
Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
The Ki-67 antigen in the new 2021 World Health Organization classification of lung neuroendocrine neoplasms.
Pelosi G, Travis WD
Pathologica 2021 Oct;113(5):377-387. doi: 10.32074/1591-951X-542. PMID: 34837096Free PMC Article
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

Therapy

Treatment of atypical pulmonary carcinoid with combination ipilimumab and nivolumab.
Nestor J, Barnaby K, Esposito M, Seetharamu N
BMJ Case Rep 2019 Nov 28;12(11) doi: 10.1136/bcr-2019-231029. PMID: 31780616Free PMC Article

Prognosis

Expression patterns of novel immunotherapy targets in intermediate- and high-grade lung neuroendocrine neoplasms.
Ferencz B, Török K, Pipek O, Fillinger J, Csende K, Lantos A, Černeková R, Mitták M, Škarda J, Delongová P, Megyesfalvi E, Schelch K, Lang C, Solta A, Boettiger K, Brcic L, Lindenmann J, Rényi-Vámos F, Aigner C, Berta J, Megyesfalvi Z, Döme B
Cancer Immunol Immunother 2024 May 2;73(6):114. doi: 10.1007/s00262-024-03704-7. PMID: 38693435Free PMC Article
Updates on lung neuroendocrine neoplasm classification.
Vocino Trucco G, Righi L, Volante M, Papotti M
Histopathology 2024 Jan;84(1):67-85. Epub 2023 Oct 4 doi: 10.1111/his.15058. PMID: 37794655
The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.
Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

Clinical prediction guides

[(68)Ga]Ga-Pentixafor PET/CT imaging for in vivo CXCR4 receptor mapping in different lung cancer histologic sub-types: correlation with quantitative receptors' density by immunochemistry techniques.
Watts A, Singh B, Singh H, Bal A, Kaur H, Dhanota N, Arora SK, Mittal BR, Behera D
Eur J Nucl Med Mol Imaging 2023 Mar;50(4):1216-1227. Epub 2022 Dec 9 doi: 10.1007/s00259-022-06059-2. PMID: 36482077
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

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