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Lung Neuroendocrine Tumor G1

MedGen UID:
310952
Concept ID:
C1708788
Neoplastic Process
Synonyms: Lung NET G1; Lung NET Grade 1; Lung NET, Grade 1; Lung Neuroendocrine Tumor Grade 1; Lung Neuroendocrine Tumor, Grade 1; Lung Typical Carcinoid Tumor; Typical carcinoid tumor of lung; Well-differentiated neuroendocrine tumor grade 1 of lung
SNOMED CT: Typical carcinoid tumor of lung (1287173009); Well-differentiated neuroendocrine tumor grade 1 of lung (1287173009)

Definition

A neuroendocrine tumor of the lung characterized by the absence of necrosis and the presence of less than 2 mitoses per 10 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Neuroendocrine Tumor G1

Professional guidelines

PubMed

Fa'ak F, Buni M, Falohun A, Lu H, Song J, Johnson DH, Zobniw CM, Trinh VA, Awiwi MO, Tahon NH, Elsayes KM, Ludford K, Montazari EJ, Chernis J, Dimitrova M, Sandigursky S, Sparks JA, Abu-Shawer O, Rahma O, Thanarajasingam U, Zeman AM, Talukder R, Singh N, Chung SH, Grivas P, Daher M, Abudayyeh A, Osman I, Weber J, Tayar JH, Suarez-Almazor ME, Abdel-Wahab N, Diab A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006814. PMID: 37328287Free PMC Article
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Fa'ak F, Buni M, Falohun A, Lu H, Song J, Johnson DH, Zobniw CM, Trinh VA, Awiwi MO, Tahon NH, Elsayes KM, Ludford K, Montazari EJ, Chernis J, Dimitrova M, Sandigursky S, Sparks JA, Abu-Shawer O, Rahma O, Thanarajasingam U, Zeman AM, Talukder R, Singh N, Chung SH, Grivas P, Daher M, Abudayyeh A, Osman I, Weber J, Tayar JH, Suarez-Almazor ME, Abdel-Wahab N, Diab A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006814. PMID: 37328287Free PMC Article
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV
Clin Cancer Res 2019 Aug 15;25(16):4966-4972. Epub 2019 Apr 15 doi: 10.1158/1078-0432.CCR-19-0160. PMID: 30988082Free PMC Article
Ohmoto A, Rokutan H, Yachida S
Int J Mol Sci 2017 Jan 13;18(1) doi: 10.3390/ijms18010143. PMID: 28098761Free PMC Article

Diagnosis

Xu L, Yu G, Jiang L, Song X, Qu G, Luo J, Cai L
Appl Immunohistochem Mol Morphol 2023 Nov-Dec 01;31(10):668-672. Epub 2023 Sep 26 doi: 10.1097/PAI.0000000000001160. PMID: 37751245
Fa'ak F, Buni M, Falohun A, Lu H, Song J, Johnson DH, Zobniw CM, Trinh VA, Awiwi MO, Tahon NH, Elsayes KM, Ludford K, Montazari EJ, Chernis J, Dimitrova M, Sandigursky S, Sparks JA, Abu-Shawer O, Rahma O, Thanarajasingam U, Zeman AM, Talukder R, Singh N, Chung SH, Grivas P, Daher M, Abudayyeh A, Osman I, Weber J, Tayar JH, Suarez-Almazor ME, Abdel-Wahab N, Diab A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006814. PMID: 37328287Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Pelosi G, Pattini L, Morana G, Fabbri A, Faccinetto A, Fazio N, Valeri B, Sonzogni A
Histol Histopathol 2017 Mar;32(3):223-241. Epub 2016 Sep 15 doi: 10.14670/HH-11-822. PMID: 27628949
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Therapy

Nabet BY, Hamidi H, Lee MC, Banchereau R, Morris S, Adler L, Gayevskiy V, Elhossiny AM, Srivastava MK, Patil NS, Smith KA, Jesudason R, Chan C, Chang PS, Fernandez M, Rost S, McGinnis LM, Koeppen H, Gay CM, Minna JD, Heymach JV, Chan JM, Rudin CM, Byers LA, Liu SV, Reck M, Shames DS
Cancer Cell 2024 Mar 11;42(3):429-443.e4. Epub 2024 Feb 15 doi: 10.1016/j.ccell.2024.01.010. PMID: 38366589
Fa'ak F, Buni M, Falohun A, Lu H, Song J, Johnson DH, Zobniw CM, Trinh VA, Awiwi MO, Tahon NH, Elsayes KM, Ludford K, Montazari EJ, Chernis J, Dimitrova M, Sandigursky S, Sparks JA, Abu-Shawer O, Rahma O, Thanarajasingam U, Zeman AM, Talukder R, Singh N, Chung SH, Grivas P, Daher M, Abudayyeh A, Osman I, Weber J, Tayar JH, Suarez-Almazor ME, Abdel-Wahab N, Diab A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006814. PMID: 37328287Free PMC Article
Nagai S
Curr Opin Organ Transplant 2023 Jun 1;28(3):222-227. Epub 2023 Apr 10 doi: 10.1097/MOT.0000000000001063. PMID: 37040627
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993

Prognosis

Niknafs N, Balan A, Cherry C, Hummelink K, Monkhorst K, Shao XM, Belcaid Z, Marrone KA, Murray J, Smith KN, Levy B, Feliciano J, Hann CL, Lam V, Pardoll DM, Karchin R, Seiwert TY, Brahmer JR, Forde PM, Velculescu VE, Anagnostou V
Nat Med 2023 Feb;29(2):440-449. Epub 2023 Jan 26 doi: 10.1038/s41591-022-02163-w. PMID: 36702947Free PMC Article
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Clinical prediction guides

Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D, Saha LK, Lee CF, Elenbaas B, Desai P, Sebastian R, Sharma AK, Abel M, Schroeder B, Krishnamurthy M, Kumar R, Roper N, Aladjem M, Zenke FT, Ohler ZW, Pommier Y, Thomas A
EMBO Mol Med 2023 Aug 7;15(8):e17313. Epub 2023 Jul 25 doi: 10.15252/emmm.202217313. PMID: 37491889Free PMC Article
Capdevila J, Hernando J, Teule A, Lopez C, Garcia-Carbonero R, Benavent M, Custodio A, Garcia-Alvarez A, Cubillo A, Alonso V, Carmona-Bayonas A, Alonso-Gordoa T, Crespo G, Jimenez-Fonseca P, Blanco M, Viudez A, La Casta A, Sevilla I, Segura A, Llanos M, Landolfi S, Nuciforo P, Manzano JL
Nat Commun 2023 May 23;14(1):2973. doi: 10.1038/s41467-023-38611-5. PMID: 37221181Free PMC Article
Niknafs N, Balan A, Cherry C, Hummelink K, Monkhorst K, Shao XM, Belcaid Z, Marrone KA, Murray J, Smith KN, Levy B, Feliciano J, Hann CL, Lam V, Pardoll DM, Karchin R, Seiwert TY, Brahmer JR, Forde PM, Velculescu VE, Anagnostou V
Nat Med 2023 Feb;29(2):440-449. Epub 2023 Jan 26 doi: 10.1038/s41591-022-02163-w. PMID: 36702947Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Recent systematic reviews

Marchevsky AM, Hendifar A, Walts AE
Mod Pathol 2018 Oct;31(10):1523-1531. Epub 2018 May 25 doi: 10.1038/s41379-018-0076-9. PMID: 29802361

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