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Non-Functioning Lung Neuroendocrine Tumor

MedGen UID:
1781612
•Concept ID:
C5447390
•
Neoplastic Process
Synonym: Non-Functioning Lung Carcinoid Tumor

Definition

A lung neuroendocrine tumor that is not associated with carcinoid syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Functioning Lung Neuroendocrine Tumor

Recent clinical studies

Etiology

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study.
Fazio N, Gervaso L, Halfdanarson TR, La Salvia A, Hofland J, Hernando J, Sonbol MB, Garcia-Carbonero R, Capdevila J, de Herder WW, Koumarianou A, Kaltsas G, Rossi M, Grozinsky-Glasberg S, Oleinikov K, Boselli S, Tamayo D, Bagnardi V, Laffi A, Rubino M, Spada F
Eur J Cancer 2021 Sep;154:246-252. Epub 2021 Jun 30 doi: 10.1016/j.ejca.2021.06.029. PMID: 34298375Free PMC Article
Outcome of Patients With Metastatic Lung Neuroendocrine Tumors Submitted to First Line Monotherapy With Somatostatin Analogs.
Lenotti E, Alberti A, Spada F, Amoroso V, Maisonneuve P, Grisanti S, Baggi A, Bianchi S, Fazio N, Berruti A
Front Endocrinol (Lausanne) 2021;12:669484. Epub 2021 Apr 27 doi: 10.3389/fendo.2021.669484. PMID: 33986731Free PMC Article
Unusual paraneoplastic neurological syndrome secondary to a well differentiated pancreatic neuroendocrine tumor: a case report and review of the literature.
Brizzi MP, Sonetto C, Tampellini M, Di Maio M, Volante M, Scagliotti GV
BMC Cancer 2015 Nov 18;15:914. doi: 10.1186/s12885-015-1923-4. PMID: 26582328Free PMC Article
Neuroendocrine gastro-enteropancreatic tumors - from eminence based to evidence-based medicine - A Scandinavian view.
Öberg K
Scand J Gastroenterol 2015 Jun;50(6):727-39. Epub 2015 Apr 8 doi: 10.3109/00365521.2015.1033001. PMID: 25855088

Diagnosis

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Neuroendocrine gastro-enteropancreatic tumors - from eminence based to evidence-based medicine - A Scandinavian view.
Öberg K
Scand J Gastroenterol 2015 Jun;50(6):727-39. Epub 2015 Apr 8 doi: 10.3109/00365521.2015.1033001. PMID: 25855088
Magnetic resonance imaging in the detection of pancreatic neoplasms.
Zhong L
J Dig Dis 2007 Aug;8(3):128-32. doi: 10.1111/j.1443-9573.2007.00297.x. PMID: 17650223
Malignant non-functioning pheochromocytoma of the organ of Zuckerkandl masquerading as a primary carcinoma of the prostate with metastases.
Melicow MM, Uson AC, Veenema RJ
J Urol 1973 Jul;110(1):97-103. doi: 10.1016/s0022-5347(17)60126-5. PMID: 4713370

Therapy

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Outcome of Patients With Metastatic Lung Neuroendocrine Tumors Submitted to First Line Monotherapy With Somatostatin Analogs.
Lenotti E, Alberti A, Spada F, Amoroso V, Maisonneuve P, Grisanti S, Baggi A, Bianchi S, Fazio N, Berruti A
Front Endocrinol (Lausanne) 2021;12:669484. Epub 2021 Apr 27 doi: 10.3389/fendo.2021.669484. PMID: 33986731Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Somatostatin receptor scintigraphy versus chromogranin A assay in the management of patients with neuroendocrine tumors of different types: clinical role.
Cimitan M, Buonadonna A, Cannizzaro R, Canzonieri V, Borsatti E, Ruffo R, De Apollonia L
Ann Oncol 2003 Jul;14(7):1135-41. doi: 10.1093/annonc/mdg279. PMID: 12853358
Somatostatin receptors: clinical implications for endocrinology and oncology.
Lamberts SW, de Herder WW, van Koetsveld PM, Koper JW, van der Lely AJ, Visser-Wisselaar HA, Hofland LJ
Ciba Found Symp 1995;190:222-36; discussion 236-9. doi: 10.1002/9780470514733.ch14. PMID: 7587649

Prognosis

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Outcome of Patients With Metastatic Lung Neuroendocrine Tumors Submitted to First Line Monotherapy With Somatostatin Analogs.
Lenotti E, Alberti A, Spada F, Amoroso V, Maisonneuve P, Grisanti S, Baggi A, Bianchi S, Fazio N, Berruti A
Front Endocrinol (Lausanne) 2021;12:669484. Epub 2021 Apr 27 doi: 10.3389/fendo.2021.669484. PMID: 33986731Free PMC Article
Chemotherapy in NEN: still has a role?
Espinosa-Olarte P, La Salvia A, Riesco-Martinez MC, Anton-Pascual B, Garcia-Carbonero R
Rev Endocr Metab Disord 2021 Sep;22(3):595-614. Epub 2021 Apr 11 doi: 10.1007/s11154-021-09638-0. PMID: 33843007Free PMC Article
Unusual paraneoplastic neurological syndrome secondary to a well differentiated pancreatic neuroendocrine tumor: a case report and review of the literature.
Brizzi MP, Sonetto C, Tampellini M, Di Maio M, Volante M, Scagliotti GV
BMC Cancer 2015 Nov 18;15:914. doi: 10.1186/s12885-015-1923-4. PMID: 26582328Free PMC Article
Biological aspects of neuroendocrine gastro-enteropancreatic tumours.
Oberg K
Digestion 1996;57 Suppl 1:42-4. doi: 10.1159/000201393. PMID: 8813467

Clinical prediction guides

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Exploring the Possible Prognostic Role of B-Lymphocyte Stimulator (BLyS) in a Large Series of Patients with Neuroendocrine Tumors.
Grimaldi F, Vescini F, Tonelli V, Pistis C, Kara E, Triggiani V, Tonutti E, Curcio F, Fabris M
Endocr Metab Immune Disord Drug Targets 2018;18(6):618-625. doi: 10.2174/1871530318666180529111224. PMID: 29807524

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