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Pineal body neoplasm

MedGen UID:
237252
•Concept ID:
C1412004
•
Neoplastic Process
Synonyms: Neoplasm of Pineal Area; neoplasm of pineal area; neoplasm of pineal body; Neoplasm of Pineal Region; neoplasm of pineal region; Neoplasm of the Pineal Area; neoplasm of the pineal area; Neoplasm of the Pineal Region; neoplasm of the pineal region; Pineal Area Neoplasm; pineal area neoplasm; Pineal Area Tumor; pineal area tumor; pineal area tumour; Pineal Body Neoplasm; pineal body neoplasm; pineal body neoplasm (disease); Pineal Body Tumor; pineal body tumor; pineal body tumour; Pineal Neoplasm; pineal neoplasm; Pineal Region Neoplasm; pineal region neoplasm; Pineal Region Tumor; pineal region tumor; pineal region tumour; Pineal Tumor; pineal tumor; pineal tumour; Pinealoma; pinealoma; Tumor of Pineal Area; tumor of pineal area; tumor of pineal body; Tumor of Pineal Region; tumor of pineal region; Tumor of the Pineal Area; tumor of the pineal area; Tumor of the Pineal Region; tumor of the pineal region; tumour of pineal area; tumour of pineal body; tumour of pineal region; tumour of the pineal area; tumour of the pineal region
 
Monarch Initiative: MONDO:0021232

Definition

A benign or malignant neoplasm that affects the pineal region. [from NCI]

Professional guidelines

PubMed

SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience.
Duffner PK, Horowitz ME, Krischer JP, Burger PC, Cohen ME, Sanford RA, Friedman HS, Kun LE
Neuro Oncol 1999 Apr;1(2):152-61. doi: 10.1093/neuonc/1.2.152. PMID: 11554387Free PMC Article
Intracranial tumors in childhood--concepts of treatment and prognosis.
Schulte FJ
Neuropediatrics 1984 Feb;15(1):3-12. doi: 10.1055/s-2008-1052332. PMID: 6324015

Recent clinical studies

Etiology

Stereotactic Radiosurgery for Pineal Region Tumors.
Mathieu D, Iorio-Morin C
Prog Neurol Surg 2019;34:173-183. Epub 2019 May 16 doi: 10.1159/000493062. PMID: 31096261
Retinoblastoma and Neuroblastoma Predisposition and Surveillance.
Kamihara J, Bourdeaut F, Foulkes WD, Molenaar JJ, Mossé YP, Nakagawara A, Parareda A, Scollon SR, Schneider KW, Skalet AH, States LJ, Walsh MF, Diller LR, Brodeur GM
Clin Cancer Res 2017 Jul 1;23(13):e98-e106. doi: 10.1158/1078-0432.CCR-17-0652. PMID: 28674118Free PMC Article
Contemporary management of pineocytoma.
Clark AJ, Sughrue ME, Aranda D, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):403-7, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.004. PMID: 21801989
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Diagnosis

Retinoblastoma and Neuroblastoma Predisposition and Surveillance.
Kamihara J, Bourdeaut F, Foulkes WD, Molenaar JJ, Mossé YP, Nakagawara A, Parareda A, Scollon SR, Schneider KW, Skalet AH, States LJ, Walsh MF, Diller LR, Brodeur GM
Clin Cancer Res 2017 Jul 1;23(13):e98-e106. doi: 10.1158/1078-0432.CCR-17-0652. PMID: 28674118Free PMC Article
Stereotactic radiosurgery for pineal region tumors.
Hanft SJ, Isaacson SR, Bruce JN
Neurosurg Clin N Am 2011 Jul;22(3):413-20, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.002. PMID: 21801991
Surgical approaches to the pineal region.
Kennedy BC, Bruce JN
Neurosurg Clin N Am 2011 Jul;22(3):367-80, viii. doi: 10.1016/j.nec.2011.05.007. PMID: 21801985
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Therapy

Peritoneal Dissemination via Ventriculoperitoneal Shunt of a Pineoblastoma.
Zhang R, Li J, Hui X, Zhang S
Neurology 2024 Nov 12;103(9):e209937. Epub 2024 Oct 4 doi: 10.1212/WNL.0000000000209937. PMID: 39365972
Delayed-onset seesaw nystagmus following brain irradiation.
Fridman G, Distefano A
Digit J Ophthalmol 2021 Jun;27(2):29-32. Epub 2021 May 17 doi: 10.5693/djo.02.2020.12.002. PMID: 34512208Free PMC Article
Primary sex headache in adolescents.
Gelfand AA, Goadsby PJ
Pediatrics 2012 Aug;130(2):e439-41. Epub 2012 Jul 2 doi: 10.1542/peds.2011-2624. PMID: 22753551Free PMC Article
Trilateral retinoblastoma.
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402
Trilateral retinoblastoma.
Meadows A
Med Pediatr Oncol 1986;14(6):323-6. doi: 10.1002/mpo.2950140609. PMID: 3784984

Prognosis

Adult Brain Tumors and Pseudotumors: Interesting (Bizarre) Cases.
Causil LD, Ames R, Puac P, Castillo M
Neuroimaging Clin N Am 2016 Nov;26(4):667-689. doi: 10.1016/j.nic.2016.06.012. PMID: 27712799
Stereotactic radiosurgery for pineal region tumors.
Hanft SJ, Isaacson SR, Bruce JN
Neurosurg Clin N Am 2011 Jul;22(3):413-20, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.002. PMID: 21801991
Contemporary management of pineoblastoma.
Tate MC, Rutkowski MJ, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):409-12, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.001. PMID: 21801990
Contemporary management of pineocytoma.
Clark AJ, Sughrue ME, Aranda D, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):403-7, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.004. PMID: 21801989
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Clinical prediction guides

Pineal teratoma with nephroblastic component in a newborn male: Case report and review of the literature.
Thoe J, Ducis K, Eldomery MK, Marshall M, Ferguson M, Vortmeyer AO, Raskin JS, Coven SL
J Clin Neurosci 2020 Oct;80:207-214. Epub 2020 Aug 27 doi: 10.1016/j.jocn.2020.07.044. PMID: 33099347
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Chung PED, Gendoo DMA, Ghanbari-Azarnier R, Liu JC, Jiang Z, Tsui J, Wang DY, Xiao X, Li B, Dubuc A, Shih D, Remke M, Ho B, Garzia L, Ben-David Y, Kang SG, Croul S, Haibe-Kains B, Huang A, Taylor MD, Zacksenhaus E
Nat Commun 2020 Apr 14;11(1):1825. doi: 10.1038/s41467-020-15585-2. PMID: 32286280Free PMC Article
Intracranial growing teratoma syndrome observed at 44 months after initial treatment; a case presentation and literature review.
Yanagisawa S, Okamoto K, Yamaguchi S, Tamai Y, Fujitani M, Inoue M, Hara T
Childs Nerv Syst 2020 Apr;36(4):865-868. Epub 2019 Dec 18 doi: 10.1007/s00381-019-04443-2. PMID: 31853895
Multiple Cavernous Malformations of Brain, Chest, and Skin: A Rare Case of an Infant and Literature Review.
Xu X, Li J, Chen C, Wang F, Li F
World Neurosurg 2018 Dec;120:177-180. Epub 2018 Aug 29 doi: 10.1016/j.wneu.2018.08.152. PMID: 30170143
Extraneural metastasis of intracranial germinoma with syncytiotrophoblastic giant cells--case report.
Akai T, Iizuka H, Kadoya S, Nojima T
Neurol Med Chir (Tokyo) 1998 Sep;38(9):574-7. doi: 10.2176/nmc.38.574. PMID: 9805904

Recent systematic reviews

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Radiotherapy for papillary tumor of the pineal region: A systematic review of the literature.
Lancia A, Becherini C, Detti B, Bottero M, Baki M, Cancelli A, Ferlosio A, Scoccianti S, Sun R, Livi L, Ingrosso G
Clin Neurol Neurosurg 2020 Mar;190:105646. Epub 2019 Dec 21 doi: 10.1016/j.clineuro.2019.105646. PMID: 31896492
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225

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