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Abnormal fetal physiology

MedGen UID:
1814231
Concept ID:
C5676658
Finding
Synonyms: Functional fetal anomaly; Functional foetal anomaly
 
HPO: HP:0034059

Definition

Any functional anomaly of the fetus. [from HPO]

Professional guidelines

PubMed

American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics; Committee on Genetics; Society for Maternal-Fetal Medicine
Obstet Gynecol 2020 Oct;136(4):e48-e69. doi: 10.1097/AOG.0000000000004084. PMID: 32804883
Speiser PW, Arlt W, Auchus RJ, Baskin LS, Conway GS, Merke DP, Meyer-Bahlburg HFL, Miller WL, Murad MH, Oberfield SE, White PC
J Clin Endocrinol Metab 2018 Nov 1;103(11):4043-4088. doi: 10.1210/jc.2018-01865. PMID: 30272171Free PMC Article
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Qin Y, Yao Y, Liu N, Wang B, Liu L, Li H, Gao T, Xu R, Wang X, Zhang F, Song J
BMC Med Genomics 2023 Oct 25;16(1):262. doi: 10.1186/s12920-023-01697-3. PMID: 37880672Free PMC Article
Peyvandi S, Rollins C
Can J Cardiol 2023 Feb;39(2):115-122. Epub 2022 Sep 27 doi: 10.1016/j.cjca.2022.09.020. PMID: 36174913Free PMC Article
Friedman KG, Tworetzky W
Arch Cardiovasc Dis 2020 Feb;113(2):121-128. Epub 2020 Feb 26 doi: 10.1016/j.acvd.2019.06.007. PMID: 32113817
Wou K, DeBie I, Carroll J, Brock JA, Douglas Wilson R
J Obstet Gynaecol Can 2019 Jan;41(1):64-67. doi: 10.1016/j.jogc.2018.06.016. PMID: 30580830
Oneda B, Rauch A
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:53-63. Epub 2017 Jan 23 doi: 10.1016/j.bpobgyn.2017.01.003. PMID: 28215395

Diagnosis

Peyvandi S, Rollins C
Can J Cardiol 2023 Feb;39(2):115-122. Epub 2022 Sep 27 doi: 10.1016/j.cjca.2022.09.020. PMID: 36174913Free PMC Article
Yamashiro KJ, Galganski LA, Hirose S
Semin Pediatr Surg 2019 Aug;28(4):150822. Epub 2019 Jul 18 doi: 10.1053/j.sempedsurg.2019.07.005. PMID: 31451176
Wou K, DeBie I, Carroll J, Brock JA, Douglas Wilson R
J Obstet Gynaecol Can 2019 Jan;41(1):64-67. doi: 10.1016/j.jogc.2018.06.016. PMID: 30580830
Gournay V
Arch Cardiovasc Dis 2011 Nov;104(11):578-85. Epub 2010 Sep 21 doi: 10.1016/j.acvd.2010.06.006. PMID: 22117910
Socol ML, Tamura RK, Sabbagha RE
Clin Obstet Gynecol 1984 Jun;27(2):352-8. doi: 10.1097/00003081-198406000-00010. PMID: 6378471

Therapy

Conrad C, Newberry D
Adv Neonatal Care 2019 Jun;19(3):179-187. doi: 10.1097/ANC.0000000000000590. PMID: 30720481
Caputo C, Wood E, Jabbour L
Birth Defects Res C Embryo Today 2016 Jun;108(2):174-80. Epub 2016 Jun 13 doi: 10.1002/bdrc.21129. PMID: 27297122
Olson-Chen C, Seligman NS
Crit Care Clin 2016 Jan;32(1):29-41. Epub 2015 Oct 6 doi: 10.1016/j.ccc.2015.08.006. PMID: 26600442
Ruiz V, Manubens E, Puig L
Actas Dermosifiliogr 2014 Nov;105(9):813-21. Epub 2013 Dec 4 doi: 10.1016/j.ad.2013.06.005. PMID: 24314892
Lancet 1969 Sep 6;2(7619):530. PMID: 4184847

Prognosis

Society for Maternal-Fetal Medicine (SMFM), Chyu JK
Am J Obstet Gynecol 2021 Nov;225(5):B26-B27. Epub 2021 Sep 8 doi: 10.1016/j.ajog.2021.06.047. PMID: 34507798
Kirby E, Keijzer R
Pediatr Surg Int 2020 Apr;36(4):415-429. Epub 2020 Feb 18 doi: 10.1007/s00383-020-04625-z. PMID: 32072236
Oneda B, Rauch A
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:53-63. Epub 2017 Jan 23 doi: 10.1016/j.bpobgyn.2017.01.003. PMID: 28215395
Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH
Am J Obstet Gynecol 2005 Apr;192(4):1005-21. doi: 10.1016/j.ajog.2004.12.093. PMID: 15846173
Rosenberg HS
Pediatr Pathol 1990;10(1-2):103-15. doi: 10.3109/15513819009067100. PMID: 2179916

Clinical prediction guides

Rosato S, Unger S, Campos-Xavier B, Caraffi SG, Beltrami L, Pollazzon M, Ivanovski I, Castori M, Bonasoni MP, Comitini G, Nikkels PGJ, Lindstrom K, Umandap C, Superti-Furga A, Garavelli L
Genes (Basel) 2022 Jan 28;13(2) doi: 10.3390/genes13020261. PMID: 35205306Free PMC Article
Conrad C, Newberry D
Adv Neonatal Care 2019 Jun;19(3):179-187. doi: 10.1097/ANC.0000000000000590. PMID: 30720481
Lord J, McMullan DJ, Eberhardt RY, Rinck G, Hamilton SJ, Quinlan-Jones E, Prigmore E, Keelagher R, Best SK, Carey GK, Mellis R, Robart S, Berry IR, Chandler KE, Cilliers D, Cresswell L, Edwards SL, Gardiner C, Henderson A, Holden ST, Homfray T, Lester T, Lewis RA, Newbury-Ecob R, Prescott K, Quarrell OW, Ramsden SC, Roberts E, Tapon D, Tooley MJ, Vasudevan PC, Weber AP, Wellesley DG, Westwood P, White H, Parker M, Williams D, Jenkins L, Scott RH, Kilby MD, Chitty LS, Hurles ME, Maher ER; Prenatal Assessment of Genomes and Exomes Consortium
Lancet 2019 Feb 23;393(10173):747-757. Epub 2019 Jan 31 doi: 10.1016/S0140-6736(18)31940-8. PMID: 30712880Free PMC Article
Murray H
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:2-11. Epub 2016 Oct 21 doi: 10.1016/j.bpobgyn.2016.10.008. PMID: 27866937
Gardner RJ
Clin Anat 2016 Jul;29(5):540-6. Epub 2016 Apr 4 doi: 10.1002/ca.22714. PMID: 26990310

Recent systematic reviews

Kirkham JK, Estepp JH, Weiss MJ, Rashkin SR
JAMA Netw Open 2023 Oct 2;6(10):e2337484. doi: 10.1001/jamanetworkopen.2023.37484. PMID: 37851445Free PMC Article
Ferreira RG, Mendonça CR, Gonçalves Ramos LL, de Abreu Tacon FS, Naves do Amaral W, Ruano R
J Matern Fetal Neonatal Med 2022 Dec;35(25):6199-6212. Epub 2021 Apr 25 doi: 10.1080/14767058.2021.1909563. PMID: 33899664
Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD
PLoS One 2020;15(12):e0242367. Epub 2020 Dec 15 doi: 10.1371/journal.pone.0242367. PMID: 33320867Free PMC Article
Caputo C, Wood E, Jabbour L
Birth Defects Res C Embryo Today 2016 Jun;108(2):174-80. Epub 2016 Jun 13 doi: 10.1002/bdrc.21129. PMID: 27297122
Dean SV, Lassi ZS, Imam AM, Bhutta ZA
Reprod Health 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. PMID: 25415364Free PMC Article

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