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Elevated fetal middle cerebral artery peak systolic velocity

MedGen UID:
1814351
•Concept ID:
C5676782
•
Finding
HPO: HP:0034191

Definition

Increased peak systolic velocity of the fetal middle cerebral artery (MCA) as evaluated by Doppler ultrasound. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated fetal middle cerebral artery peak systolic velocity

Professional guidelines

PubMed

Circulating N-terminal pro-B-type natriuretic peptide in fetal anemia before and after treatment.
Merz WM, Kübler K, Fimmers R, Stoffel-Wagner B, Geipel A, Gembruch U
Pediatr Res 2012 Aug;72(2):174-8. doi: 10.1038/pr.2012.53. PMID: 22546865
Management of anti-Jka alloimmunization.
Franco A, Rossi K, Krugh D, O'Shaughnessy R
J Reprod Med 2009 Mar;54(3):121-5. PMID: 19370894
The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia.
Moise KJ Jr
Am J Obstet Gynecol 2008 Feb;198(2):161.e1-4. doi: 10.1016/j.ajog.2007.10.788. PMID: 18226612

Recent clinical studies

Etiology

Elevated middle cerebral artery peak systolic velocity and risk of death in donor twin affected by twin-twin transfusion syndrome but not twin anemia-polycythemia sequence.
Espinoza J, Agarwal N, Johnson A, Hernandez-Andrade E, Backley S, Papanna R, Bergh EP
Ultrasound Obstet Gynecol 2024 Aug;64(2):222-227. Epub 2024 Jun 22 doi: 10.1002/uog.27629. PMID: 38437460
The effect of nuchal umbilical cord on fetal cardiac and cerebral circulation-cross-sectional study.
Murlewska J, Sylwestrzak O, Poszwa P, Respondek-Liberska M
J Perinat Med 2021 Jun 25;49(5):590-595. Epub 2021 Feb 11 doi: 10.1515/jpm-2020-0316. PMID: 33567478
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Management of anti-Jka alloimmunization.
Franco A, Rossi K, Krugh D, O'Shaughnessy R
J Reprod Med 2009 Mar;54(3):121-5. PMID: 19370894
The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia.
Moise KJ Jr
Am J Obstet Gynecol 2008 Feb;198(2):161.e1-4. doi: 10.1016/j.ajog.2007.10.788. PMID: 18226612

Diagnosis

Massive fetomaternal hemorrhage: A case report.
Weinhold V, Rauber S, Hollatz-Galuschki E, Seybold M, Kainer F, Kouskouti C
Z Geburtshilfe Neonatol 2024 Aug;228(4):382-385. Epub 2024 Jan 29 doi: 10.1055/a-2238-3217. PMID: 38286411
Fetal and neonatal abnormalities due to congenital syphilis: A literature review.
David M, Hcini N, Mandelbrot L, Sibiude J, Picone O
Prenat Diagn 2022 May;42(5):643-655. Epub 2022 Apr 9 doi: 10.1002/pd.6135. PMID: 35352829
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Management of anti-Jka alloimmunization.
Franco A, Rossi K, Krugh D, O'Shaughnessy R
J Reprod Med 2009 Mar;54(3):121-5. PMID: 19370894
The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia.
Moise KJ Jr
Am J Obstet Gynecol 2008 Feb;198(2):161.e1-4. doi: 10.1016/j.ajog.2007.10.788. PMID: 18226612

Therapy

Perimortem Demonstration and Treatment of Recipient-to-Donor Transfusion in Monochorionic-Diamniotic Twin Gestation.
Parrott J, Schwartz T, Cowles T, Holland M, Weiner CP
Fetal Diagn Ther 2017;42(3):232-235. Epub 2017 Jun 2 doi: 10.1159/000476033. PMID: 28571031
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome.
Trieu NT, Weingertner AS, Guerra F, Dautun D, Kohler M, Vayssière C, Nisand I, Favre R
Prenat Diagn 2012 Feb;32(2):127-30. doi: 10.1002/pd.2907. PMID: 22418955
Changes in blood velocities of fetal circulation in association with fetal heart rate abnormalities: effect of sublingual administration of nifedipine.
Hata T, Manabe A, Hata K, Kitao M
Am J Perinatol 1995 Mar;12(2):80-1. doi: 10.1055/s-2007-994408. PMID: 7779201

Prognosis

Predictors of Poor Outcomes in Monochorionic Diamniotic Twin Pregnancies Complicated by Selective Fetal Growth Restriction.
Soni S, Gebb J, Miller K, Oliver ER, Teefey CP, Moldenhauer JS, Khalek N
Fetal Diagn Ther 2024;51(3):300-309. Epub 2024 Feb 17 doi: 10.1159/000537861. PMID: 38368864
The effect of nuchal umbilical cord on fetal cardiac and cerebral circulation-cross-sectional study.
Murlewska J, Sylwestrzak O, Poszwa P, Respondek-Liberska M
J Perinat Med 2021 Jun 25;49(5):590-595. Epub 2021 Feb 11 doi: 10.1515/jpm-2020-0316. PMID: 33567478
Can middle cerebral artery peak systolic velocity predict polycythemia in monochorionic-diamniotic twins? Evidence from a prospective cohort study.
Fishel-Bartal M, Weisz B, Mazaki-Tovi S, Ashwal E, Chayen B, Lipitz S, Yinon Y
Ultrasound Obstet Gynecol 2016 Oct;48(4):470-475. doi: 10.1002/uog.15838. PMID: 26663574
The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia.
Moise KJ Jr
Am J Obstet Gynecol 2008 Feb;198(2):161.e1-4. doi: 10.1016/j.ajog.2007.10.788. PMID: 18226612
Massive fetal ascites causing increased middle cerebral artery systolic velocity.
Chiang G, Levine D, Hess P, Lim KH
Obstet Gynecol 2004 Nov;104(5 Pt 2):1136-40. doi: 10.1097/01.AOG.0000121830.94197.70. PMID: 15516427

Clinical prediction guides

Predictors of Poor Outcomes in Monochorionic Diamniotic Twin Pregnancies Complicated by Selective Fetal Growth Restriction.
Soni S, Gebb J, Miller K, Oliver ER, Teefey CP, Moldenhauer JS, Khalek N
Fetal Diagn Ther 2024;51(3):300-309. Epub 2024 Feb 17 doi: 10.1159/000537861. PMID: 38368864
The effect of nuchal umbilical cord on fetal cardiac and cerebral circulation-cross-sectional study.
Murlewska J, Sylwestrzak O, Poszwa P, Respondek-Liberska M
J Perinat Med 2021 Jun 25;49(5):590-595. Epub 2021 Feb 11 doi: 10.1515/jpm-2020-0316. PMID: 33567478
Can middle cerebral artery peak systolic velocity predict polycythemia in monochorionic-diamniotic twins? Evidence from a prospective cohort study.
Fishel-Bartal M, Weisz B, Mazaki-Tovi S, Ashwal E, Chayen B, Lipitz S, Yinon Y
Ultrasound Obstet Gynecol 2016 Oct;48(4):470-475. doi: 10.1002/uog.15838. PMID: 26663574
Doppler ultrasound evaluation in preeclampsia.
Lopez-Mendez MA, Martinez-Gaytan V, Cortes-Flores R, Ramos-Gonzalez RM, Ochoa-Torres MA, Garza-Veloz I, Martinez-Acuña MI, Badillo-Almaraz JI, Martinez-Fierro ML
BMC Res Notes 2013 Nov 19;6:477. doi: 10.1186/1756-0500-6-477. PMID: 24252303Free PMC Article
The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia.
Moise KJ Jr
Am J Obstet Gynecol 2008 Feb;198(2):161.e1-4. doi: 10.1016/j.ajog.2007.10.788. PMID: 18226612

Recent systematic reviews

Prenatal Diagnosis, Management, and Outcome of Fetal Subdural Haematoma: A Case Report and Systematic Review.
Cheung KW, Tan LN, Seto MTY, Moholkar S, Masson G, Kilby MD
Fetal Diagn Ther 2019;46(5):285-295. Epub 2019 Mar 12 doi: 10.1159/000496202. PMID: 30861511

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