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Fetal anemia

MedGen UID:
748513
•Concept ID:
C2349595
•
Disease or Syndrome
SNOMED CT: Fetal anemia (462166006)
 
HPO: HP:0025716

Definition

Low hemoglobin/hematocrit in a fetus as evidenced by percutaneous umbilical cord sampling and Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal anemia

Professional guidelines

PubMed

History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia--diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH
Am J Obstet Gynecol 2015 Jun;212(6):697-710. Epub 2015 Mar 27 doi: 10.1016/j.ajog.2015.01.059. PMID: 25824811

Recent clinical studies

Etiology

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Ultrasound Features of Fetal Anemia Lessons From Hemoglobin Bart Disease.
Thammavong K, Luewan S, Wanapirak C, Tongsong T
J Ultrasound Med 2021 Apr;40(4):659-674. Epub 2020 Aug 20 doi: 10.1002/jum.15436. PMID: 32815580
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203

Diagnosis

Nonimmune Hydrops Fetalis.
Swearingen C, Colvin ZA, Leuthner SR
Clin Perinatol 2020 Mar;47(1):105-121. Epub 2019 Oct 7 doi: 10.1016/j.clp.2019.10.001. PMID: 32000919
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Fetal anemia.
Argoti PS, Mari G
Minerva Ginecol 2019 Apr;71(2):97-112. Epub 2018 Oct 11 doi: 10.23736/S0026-4784.18.04334-4. PMID: 30318879
Fetal anemia.
Abbasi N, Johnson JA, Ryan G
Ultrasound Obstet Gynecol 2017 Aug;50(2):145-153. doi: 10.1002/uog.17555. PMID: 28782230
Noninvasive diagnosis of fetal anemia.
Detti L, Mari G
Clin Obstet Gynecol 2003 Dec;46(4):923-30. doi: 10.1097/00003081-200312000-00024. PMID: 14595235

Therapy

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Fetal anemia.
Abbasi N, Johnson JA, Ryan G
Ultrasound Obstet Gynecol 2017 Aug;50(2):145-153. doi: 10.1002/uog.17555. PMID: 28782230
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia--diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH
Am J Obstet Gynecol 2015 Jun;212(6):697-710. Epub 2015 Mar 27 doi: 10.1016/j.ajog.2015.01.059. PMID: 25824811

Prognosis

Pathophysiological interpretation of fetal heart rate tracings in clinical practice.
Jia YJ, Ghi T, Pereira S, Gracia Perez-Bonfils A, Chandraharan E
Am J Obstet Gynecol 2023 Jun;228(6):622-644. doi: 10.1016/j.ajog.2022.05.023. PMID: 37270259
Ultrasound Features of Fetal Anemia Lessons From Hemoglobin Bart Disease.
Thammavong K, Luewan S, Wanapirak C, Tongsong T
J Ultrasound Med 2021 Apr;40(4):659-674. Epub 2020 Aug 20 doi: 10.1002/jum.15436. PMID: 32815580
Nonimmune Hydrops Fetalis.
Swearingen C, Colvin ZA, Leuthner SR
Clin Perinatol 2020 Mar;47(1):105-121. Epub 2019 Oct 7 doi: 10.1016/j.clp.2019.10.001. PMID: 32000919
Prenatal ultrasound monitoring of homozygous α(0)-thalassemia-induced fetal anemia.
Lee HH, Mak AS, Poon CF, Leung KY
Best Pract Res Clin Obstet Gynaecol 2017 Feb;39:53-62. Epub 2016 Oct 26 doi: 10.1016/j.bpobgyn.2016.10.014. PMID: 27863915
Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia--diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH
Am J Obstet Gynecol 2015 Jun;212(6):697-710. Epub 2015 Mar 27 doi: 10.1016/j.ajog.2015.01.059. PMID: 25824811

Clinical prediction guides

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
Pathophysiological interpretation of fetal heart rate tracings in clinical practice.
Jia YJ, Ghi T, Pereira S, Gracia Perez-Bonfils A, Chandraharan E
Am J Obstet Gynecol 2023 Jun;228(6):622-644. doi: 10.1016/j.ajog.2022.05.023. PMID: 37270259
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Ultrasound Features of Fetal Anemia Lessons From Hemoglobin Bart Disease.
Thammavong K, Luewan S, Wanapirak C, Tongsong T
J Ultrasound Med 2021 Apr;40(4):659-674. Epub 2020 Aug 20 doi: 10.1002/jum.15436. PMID: 32815580
Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia--diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH
Am J Obstet Gynecol 2015 Jun;212(6):697-710. Epub 2015 Mar 27 doi: 10.1016/j.ajog.2015.01.059. PMID: 25824811

Recent systematic reviews

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Fetal thrombocytopenia in pregnancies complicated by fetal anemia due to red-cell alloimmunization: cohort study and meta-analysis.
Rosenbloom JI, Bruno AM, Conner SN, Tuuli MG, Simon LE, Macones GA, Cahill AG
J Perinatol 2019 Jul;39(7):920-926. Epub 2019 May 9 doi: 10.1038/s41372-019-0388-8. PMID: 31073147Free PMC Article
Performance of fetal middle cerebral artery peak systolic velocity for prediction of anemia in untransfused and transfused fetuses: systematic review and meta-analysis.
Martinez-Portilla RJ, Lopez-Felix J, Hawkins-Villareal A, Villafan-Bernal JR, Paz Y Miño F, Figueras F, Borrell A
Ultrasound Obstet Gynecol 2019 Dec;54(6):722-731. doi: 10.1002/uog.20273. PMID: 30932276
The Recurrence Risk of Fetomaternal Hemorrhage.
Troìa L, Al-Kouatly HB, McCurdy R, Konchak PS, Weiner S, Berghella V
Fetal Diagn Ther 2019;45(1):1-12. Epub 2018 Sep 17 doi: 10.1159/000491788. PMID: 30223274
Fetal blood sampling.
Society for Maternal-Fetal Medicine (SMFM), Berry SM, Stone J, Norton ME, Johnson D, Berghella V
Am J Obstet Gynecol 2013 Sep;209(3):170-80. doi: 10.1016/j.ajog.2013.07.014. PMID: 23978246

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