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Impaired antigen-specific response

MedGen UID:
1618415
•Concept ID:
C4531146
•
Cell or Molecular Dysfunction
Synonym: Impaired adaptive immune response
 
HPO: HP:0031404

Definition

An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [from HPO]

Professional guidelines

PubMed

Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.
Adem E, Tajebe F, Getahun M, Kiflie A, Diro E, Hailu A, Shkedy Z, Mengesha B, Mulaw T, Atnafu S, Deressa T, Mathewos B, Abate E, Modolell M, Munder M, Müller I, Takele Y, Kropf P
PLoS Negl Trop Dis 2016 Mar;10(3):e0004468. Epub 2016 Mar 10 doi: 10.1371/journal.pntd.0004468. PMID: 26962865Free PMC Article
Treatment of glomerulonephritis: will we ever have options other than steroids and cytotoxics?
Javaid B, Quigg RJ
Kidney Int 2005 May;67(5):1692-703. doi: 10.1111/j.1523-1755.2005.00266.x. PMID: 15840015
Cellular and molecular studies in the treatment of murine renal cancer.
Wiltrout RH, Gregorio TA, Fenton RG, Longo DL, Ghosh P, Murphy WJ, Komschlies KL
Semin Oncol 1995 Feb;22(1):9-16. PMID: 7855624

Recent clinical studies

Etiology

Humoral and cellular responses to repeated COVID-19 exposure in multiple sclerosis patients receiving B-cell depleting therapies: a single-center, one-year, prospective study.
Alfonso-Dunn R, Lin J, Lei J, Liu J, Roche M, De Oliveira A, Raisingani A, Kumar A, Kirschner V, Feuer G, Malin M, Sadiq SA
Front Immunol 2023;14:1194671. Epub 2023 Jun 28 doi: 10.3389/fimmu.2023.1194671. PMID: 37449202Free PMC Article
Immunomodulatory nano-preparations for rheumatoid arthritis.
Li C, Han Y, Luo X, Qian C, Li Y, Su H, Du G
Drug Deliv 2023 Dec;30(1):9-19. doi: 10.1080/10717544.2022.2152136. PMID: 36482698Free PMC Article
Vaccination in Atherosclerosis.
Nettersheim FS, De Vore L, Winkels H
Cells 2020 Nov 30;9(12) doi: 10.3390/cells9122560. PMID: 33266027Free PMC Article
Antigen-specific therapeutic approaches for autoimmunity.
Serra P, Santamaria P
Nat Biotechnol 2019 Mar;37(3):238-251. Epub 2019 Feb 25 doi: 10.1038/s41587-019-0015-4. PMID: 30804535
Immune and genetic mechanisms in COPD: possible targets for therapeutic interventions.
Tzortzaki EG, Papi A, Neofytou E, Soulitzis N, Siafakas NM
Curr Drug Targets 2013 Feb;14(2):141-8. doi: 10.2174/1389450111314020002. PMID: 23256714

Diagnosis

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8(+) T Cells.
Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH
Cancer Immunol Res 2021 Feb;9(2):184-199. Epub 2020 Dec 4 doi: 10.1158/2326-6066.CIR-20-0384. PMID: 33277233Free PMC Article
Updating ECP action mechanisms.
Heshmati F
Transfus Apher Sci 2014 Jun;50(3):330-9. Epub 2014 Apr 13 doi: 10.1016/j.transci.2014.04.003. PMID: 24837416
Autoimmune hepatitis: a comprehensive review.
Liberal R, Grant CR, Mieli-Vergani G, Vergani D
J Autoimmun 2013 Mar;41:126-39. Epub 2012 Dec 4 doi: 10.1016/j.jaut.2012.11.002. PMID: 23218932
Hypersensitivity pneumonitis.
Lacasse Y, Cormier Y
Orphanet J Rare Dis 2006 Jul 3;1:25. doi: 10.1186/1750-1172-1-25. PMID: 16817954Free PMC Article
The immunobiology of leprosy.
Kaplan G, Cohn ZA
Int Rev Exp Pathol 1986;28:45-78. PMID: 3516911

Therapy

Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels.
Qi R, Fu R, Lei X, He J, Jiang Y, Zhang L, Wu Y, Wang S, Guo X, Chen F, Nie M, Yang M, Chen Y, Zeng J, Xu J, Xiong H, Fang M, Que Y, Yao Y, Wang Y, Cao J, Ye H, Zhang Y, Zheng Z, Cheng T, Zhang J, Lin X, Yuan Q, Zhang T, Xia N
J Hepatol 2024 May;80(5):714-729. Epub 2024 Feb 7 doi: 10.1016/j.jhep.2023.12.032. PMID: 38336348
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Lander VE, Belle JI, Kingston NL, Herndon JM, Hogg GD, Liu X, Kang LI, Knolhoff BL, Bogner SJ, Baer JM, Zuo C, Borcherding NC, Lander DP, Mpoy C, Scott J, Zahner M, Rogers BE, Schwarz JK, Kim H, DeNardo DG
Cancer Discov 2022 Dec 2;12(12):2774-2799. doi: 10.1158/2159-8290.CD-22-0192. PMID: 36165893Free PMC Article
The potential of the microbiota to influence vaccine responses.
Lynn DJ, Pulendran B
J Leukoc Biol 2018 Feb;103(2):225-231. Epub 2017 Dec 28 doi: 10.1189/jlb.5MR0617-216R. PMID: 28864446Free PMC Article
Updating ECP action mechanisms.
Heshmati F
Transfus Apher Sci 2014 Jun;50(3):330-9. Epub 2014 Apr 13 doi: 10.1016/j.transci.2014.04.003. PMID: 24837416
Antigen-specific therapeutic approaches in Type 1 diabetes.
Clemente-Casares X, Tsai S, Huang C, Santamaria P
Cold Spring Harb Perspect Med 2012 Feb;2(2):a007773. doi: 10.1101/cshperspect.a007773. PMID: 22355799Free PMC Article

Prognosis

Paediatric Autoimmune Liver Disease.
Liberal R, Vergani D, Mieli-Vergani G
Dig Dis 2015;33 Suppl 2:36-46. Epub 2015 Dec 7 doi: 10.1159/000440708. PMID: 26641670
Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma.
Flecken T, Schmidt N, Hild S, Gostick E, Drognitz O, Zeiser R, Schemmer P, Bruns H, Eiermann T, Price DA, Blum HE, Neumann-Haefelin C, Thimme R
Hepatology 2014 Apr;59(4):1415-26. Epub 2014 Feb 20 doi: 10.1002/hep.26731. PMID: 24002931Free PMC Article
Immune and genetic mechanisms in COPD: possible targets for therapeutic interventions.
Tzortzaki EG, Papi A, Neofytou E, Soulitzis N, Siafakas NM
Curr Drug Targets 2013 Feb;14(2):141-8. doi: 10.2174/1389450111314020002. PMID: 23256714
Hypersensitivity pneumonitis.
Lacasse Y, Cormier Y
Orphanet J Rare Dis 2006 Jul 3;1:25. doi: 10.1186/1750-1172-1-25. PMID: 16817954Free PMC Article
Responses of the immune system to injury.
Descotes J, Choquet-Kastylevsky G, Van Ganse E, Vial T
Toxicol Pathol 2000 May-Jun;28(3):479-81. doi: 10.1177/019262330002800319. PMID: 10862568

Clinical prediction guides

Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels.
Qi R, Fu R, Lei X, He J, Jiang Y, Zhang L, Wu Y, Wang S, Guo X, Chen F, Nie M, Yang M, Chen Y, Zeng J, Xu J, Xiong H, Fang M, Que Y, Yao Y, Wang Y, Cao J, Ye H, Zhang Y, Zheng Z, Cheng T, Zhang J, Lin X, Yuan Q, Zhang T, Xia N
J Hepatol 2024 May;80(5):714-729. Epub 2024 Feb 7 doi: 10.1016/j.jhep.2023.12.032. PMID: 38336348
Humoral and cellular responses to repeated COVID-19 exposure in multiple sclerosis patients receiving B-cell depleting therapies: a single-center, one-year, prospective study.
Alfonso-Dunn R, Lin J, Lei J, Liu J, Roche M, De Oliveira A, Raisingani A, Kumar A, Kirschner V, Feuer G, Malin M, Sadiq SA
Front Immunol 2023;14:1194671. Epub 2023 Jun 28 doi: 10.3389/fimmu.2023.1194671. PMID: 37449202Free PMC Article
Analysis of CAR-Mediated Tonic Signaling.
Calderon H, Mamonkin M, Guedan S
Methods Mol Biol 2020;2086:223-236. doi: 10.1007/978-1-0716-0146-4_17. PMID: 31707680
Self-tolerance in multiple sclerosis.
Gonsette RE
Acta Neurol Belg 2012 Jun;112(2):133-40. Epub 2012 Mar 24 doi: 10.1007/s13760-012-0061-x. PMID: 22450711Free PMC Article
The immunobiology of leprosy.
Kaplan G, Cohn ZA
Int Rev Exp Pathol 1986;28:45-78. PMID: 3516911

Recent systematic reviews

Engineered antigen-specific regulatory T cells for autoimmune skin conditions.
Mukhatayev Z, Ostapchuk YO, Fang D, Le Poole IC
Autoimmun Rev 2021 Mar;20(3):102761. Epub 2021 Jan 18 doi: 10.1016/j.autrev.2021.102761. PMID: 33476816Free PMC Article

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