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Abnormal isohemagglutinin level

MedGen UID:
1697863
•Concept ID:
C5139455
•
Finding
Synonyms: Abnormal level of natural antibody to blood group agents; Abnormal natural antibody level to blood group antigens in blood (isohemagglutinin)
 
HPO: HP:0410292

Definition

An abnormal level of isohemagglutinin in the blood. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person). [from HPO]

Recent clinical studies

Etiology

Immune status of patients with inherited bone marrow failure syndromes.
Giri N, Alter BP, Penrose K, Falk RT, Pan Y, Savage SA, Williams M, Kemp TJ, Pinto LA
Am J Hematol 2015 Aug;90(8):702-8. Epub 2015 May 28 doi: 10.1002/ajh.24046. PMID: 25963299Free PMC Article
Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement.
Granchi D, Savarino L, Ciapetti G, Cenni E, Rotini R, Mieti M, Baldini N, Giunti A
J Bone Joint Surg Br 2003 Jul;85(5):758-64. PMID: 12892206
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA).
Fagiolo E, Vigevani F, Pozzetto U
Immunol Invest 1994 Nov;23(6-7):449-56. doi: 10.3109/08820139409066839. PMID: 7851962
Immunological features of Down's syndrome: a review.
Nespoli L, Burgio GR, Ugazio AG, Maccario R
J Intellect Disabil Res 1993 Dec;37 ( Pt 6):543-51. doi: 10.1111/j.1365-2788.1993.tb00324.x. PMID: 8124000
Predicting acute vs chronic childhood idiopathic thrombocytopenic purpura.
Tomar RH, Stuart MJ
Am J Dis Child 1981 May;135(5):446-9. doi: 10.1001/archpedi.1981.02130290044016. PMID: 7195147

Diagnosis

Abnormal Galactosylated-Glycans recognized by Bandeiraea Simplicifolia Lectin I in saliva of patients with breast Cancer.
Yang J, Liu X, Shu J, Hou Y, Chen M, Yu H, Ma T, Du H, Zhang J, Qiao Y, He J, Niu L, Yang F, Li Z
Glycoconj J 2020 Jun;37(3):373-394. Epub 2020 Feb 27 doi: 10.1007/s10719-020-09910-6. PMID: 32103424
Immune status of patients with inherited bone marrow failure syndromes.
Giri N, Alter BP, Penrose K, Falk RT, Pan Y, Savage SA, Williams M, Kemp TJ, Pinto LA
Am J Hematol 2015 Aug;90(8):702-8. Epub 2015 May 28 doi: 10.1002/ajh.24046. PMID: 25963299Free PMC Article
Lectin-based glycoproteomics to explore and analyze hepatocellular carcinoma-related glycoprotein markers.
Dai Z, Zhou J, Qiu SJ, Liu YK, Fan J
Electrophoresis 2009 Sep;30(17):2957-2966. doi: 10.1002/elps.200900064. PMID: 19711376
Decrease of thymic hormone serum level in Cockayne syndrome.
Bensman A, Dardenne M, Bach JF, Valleteau de Mouillac J, Lasfargues G
Pediatr Res 1982 Feb;16(2):92-4. doi: 10.1203/00006450-198202000-00002. PMID: 7058086
Predicting acute vs chronic childhood idiopathic thrombocytopenic purpura.
Tomar RH, Stuart MJ
Am J Dis Child 1981 May;135(5):446-9. doi: 10.1001/archpedi.1981.02130290044016. PMID: 7195147

Therapy

Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.
Tseng YC, Wu CY, Liu ML, Chen TH, Chiang WL, Yu YH, Jan JT, Lin KI, Wong CH, Ma C
Proc Natl Acad Sci U S A 2019 Mar 5;116(10):4200-4205. Epub 2019 Feb 19 doi: 10.1073/pnas.1819197116. PMID: 30782805Free PMC Article
An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets.
Sánchez Guiu IM, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, García-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML, Rivera J
Thromb Haemost 2015 Aug;114(2):313-24. Epub 2015 May 21 doi: 10.1160/TH14-11-0945. PMID: 25994029
Immune status of patients with inherited bone marrow failure syndromes.
Giri N, Alter BP, Penrose K, Falk RT, Pan Y, Savage SA, Williams M, Kemp TJ, Pinto LA
Am J Hematol 2015 Aug;90(8):702-8. Epub 2015 May 28 doi: 10.1002/ajh.24046. PMID: 25963299Free PMC Article
Exposure to topical bovine thrombin during surgery elicits a response against the xenogeneic carbohydrate galactose alpha1-3galactose.
Schoenecker JG, Hauck RK, Mercer MC, Parker W, Lawson JH
J Clin Immunol 2000 Nov;20(6):434-44. doi: 10.1023/a:1026455631876. PMID: 11202233
Role of zinc supplementation in type II diabetes mellitus.
Niewoehner CB, Allen JI, Boosalis M, Levine AS, Morley JE
Am J Med 1986 Jul;81(1):63-8. doi: 10.1016/0002-9343(86)90183-x. PMID: 3728555

Prognosis

Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma.
Fujiyoshi M, Kuno A, Gotoh M, Fukai M, Yokoo H, Kamachi H, Kamiyama T, Korenaga M, Mizokami M, Narimatsu H, Taketomi A; Hepatitis Glyco-biomarker Study Group
J Gastroenterol 2015 Nov;50(11):1134-44. Epub 2015 Mar 15 doi: 10.1007/s00535-015-1063-2. PMID: 25773774
Lectin-based glycoproteomics to explore and analyze hepatocellular carcinoma-related glycoprotein markers.
Dai Z, Zhou J, Qiu SJ, Liu YK, Fan J
Electrophoresis 2009 Sep;30(17):2957-2966. doi: 10.1002/elps.200900064. PMID: 19711376
Neonatal thymectomy: does it affect immune function?
Wells WJ, Parkman R, Smogorzewska E, Barr M
J Thorac Cardiovasc Surg 1998 May;115(5):1041-6. doi: 10.1016/S0022-5223(98)70403-9. PMID: 9605073
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA).
Fagiolo E, Vigevani F, Pozzetto U
Immunol Invest 1994 Nov;23(6-7):449-56. doi: 10.3109/08820139409066839. PMID: 7851962
Predicting acute vs chronic childhood idiopathic thrombocytopenic purpura.
Tomar RH, Stuart MJ
Am J Dis Child 1981 May;135(5):446-9. doi: 10.1001/archpedi.1981.02130290044016. PMID: 7195147

Clinical prediction guides

Protection against respiratory syncytial virus by inactivated influenza virus carrying a fusion protein neutralizing epitope in a chimeric hemagglutinin.
Lee YN, Hwang HS, Kim MC, Lee YT, Kim YJ, Lee FE, Kang SM
Nanomedicine 2016 Apr;12(3):759-770. Epub 2015 Dec 2 doi: 10.1016/j.nano.2015.11.007. PMID: 26656630Free PMC Article
Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy.
Qin W, Zhou Q, Yang LC, Li Z, Su BH, Luo H, Fan JM
J Intern Med 2005 Nov;258(5):467-77. doi: 10.1111/j.1365-2796.2005.01558.x. PMID: 16238683
Cell cycle properties in lymphocytes from children with myelomeningocele.
Graf WD, Oleinik OE
Eur J Pediatr Surg 1997 Dec;7 Suppl 1:15-7. doi: 10.1055/s-2008-1071202. PMID: 9497110
Immunological features of Down's syndrome: a review.
Nespoli L, Burgio GR, Ugazio AG, Maccario R
J Intellect Disabil Res 1993 Dec;37 ( Pt 6):543-51. doi: 10.1111/j.1365-2788.1993.tb00324.x. PMID: 8124000
Thrombospondin in essential thrombocythemia.
Lawler J, Cohen AM, Chao FC, Moriarty DJ
Blood 1986 Feb;67(2):555-8. PMID: 3510684

Recent systematic reviews

Cryoglobulins, Cryofibrinogens, and Cold Agglutinins in Cold Urticaria: Literature Review, Retrospective Patient Analysis, and Observational Study in 49 Patients.
Ginter K, Ahsan DM, Bizjak M, Krause K, Maurer M, Altrichter S, Terhorst-Molawi D
Front Immunol 2021;12:675451. Epub 2021 May 25 doi: 10.3389/fimmu.2021.675451. PMID: 34113348Free PMC Article

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