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Metastatic Malignant Neoplasm in the Liver

MedGen UID:
141667
Concept ID:
C0494165
Neoplastic Process
Synonyms: Cancer metastatic to liver; Hepatic metastasis; Liver Metastases; Liver Metastasis; Liver secondaries; Liver secondary cancer; Metastasis to liver; Metastatic malignant neoplasm of liver; Metastatic malignant neoplasm to liver; Metastatic Malignant Neoplasm to the Liver; Metastatic Neoplasm to the Liver; Metastatic Tumor to the Liver; Secondary malignancy of liver; Secondary malignant neoplasm of liver
SNOMED CT: Secondary malignant neoplasm of liver (94381002); Metastatic malignant neoplasm to liver (94381002); Cancer metastatic to liver (94381002); Metastatic malignant neoplasm of liver (94381002); Liver secondary cancer (94381002); Metastasis to liver (94381002); Liver secondaries (94381002); Secondary malignancy of liver (94381002); Hepatic metastasis (94381002)

Definition

A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Representative examples include carcinomas, lymphomas, melanomas, or sarcomas. [from NCI]

Professional guidelines

PubMed

Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, Muiesan P, Mirza DF, Isaac J, Laing RW, Iyer SG, Chee CE, Yong WP, Muthiah MD, Panaro F, Sanabria J, Grothey A, Moodley K, Chau I, Chan ACY, Wang CC, Menon K, Sapisochin G, Hagness M, Dueland S, Line PD, Adam R
Lancet Gastroenterol Hepatol 2021 Nov;6(11):933-946. Epub 2021 Sep 8 doi: 10.1016/S2468-1253(21)00219-3. PMID: 34506756
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Mendiratta-Lala M, Wiggermann P, Pech M, Serres-Créixams X, White SB, Davis C, Ahmed O, Parikh ND, Planert M, Thormann M, Xu Z, Collins Z, Narayanan G, Torzilli G, Cho C, Littler P, Wah TM, Solbiati L, Ziemlewicz TJ
Radiology 2024 Sep;312(3):e233051. doi: 10.1148/radiol.233051. PMID: 39225612Free PMC Article
Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KE, Hanna S, Askan G, Burman J, Ravichandran H, Zheng J, Jolissaint JS, Srouji R, Song Y, Choubey A, Kim HS, Cioffi M, van Beek E, Sigel C, Jessurun J, Velasco Riestra P, Blomstrand H, Jönsson C, Jönsson A, Lauritzen P, Buehring W, Ararso Y, Hernandez D, Vinagolu-Baur JP, Friedman M, Glidden C, Firmenich L, Lieberman G, Mejia DL, Nasar N, Mutvei AP, Paul DM, Bram Y, Costa-Silva B, Basturk O, Boudreau N, Zhang H, Matei IR, Hoshino A, Kelsen D, Sagi I, Scherz A, Scherz-Shouval R, Yarden Y, Oren M, Egeblad M, Lewis JS, Keshari K, Grandgenett PM, Hollingsworth MA, Rajasekhar VK, Healey JH, Björnsson B, Simeone DM, Tuveson DA, Iacobuzio-Donahue CA, Bromberg J, Vincent CT, O'Reilly EM, DeMatteo RP, Balachandran VP, D'Angelica MI, Kingham TP, Allen PJ, Simpson AL, Elemento O, Sandström P, Schwartz RE, Jarnagin WR, Lyden D
Nat Med 2024 Aug;30(8):2170-2180. Epub 2024 Jun 28 doi: 10.1038/s41591-024-03075-7. PMID: 38942992Free PMC Article
Strathearn LS, Stepanov AI, Font-Burgada J
Nutrients 2020 Mar 27;12(4) doi: 10.3390/nu12040933. PMID: 32230953Free PMC Article
Andersen IR, Thorup K, Jepsen BN, Mortensen FV, Nielsen DT, Rasmussen F
Acta Radiol 2019 Aug;60(8):936-945. Epub 2018 Oct 18 doi: 10.1177/0284185118806661. PMID: 30335477
Clavien PA, Petrowsky H, DeOliveira ML, Graf R
N Engl J Med 2007 Apr 12;356(15):1545-59. doi: 10.1056/NEJMra065156. PMID: 17429086

Diagnosis

Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KE, Hanna S, Askan G, Burman J, Ravichandran H, Zheng J, Jolissaint JS, Srouji R, Song Y, Choubey A, Kim HS, Cioffi M, van Beek E, Sigel C, Jessurun J, Velasco Riestra P, Blomstrand H, Jönsson C, Jönsson A, Lauritzen P, Buehring W, Ararso Y, Hernandez D, Vinagolu-Baur JP, Friedman M, Glidden C, Firmenich L, Lieberman G, Mejia DL, Nasar N, Mutvei AP, Paul DM, Bram Y, Costa-Silva B, Basturk O, Boudreau N, Zhang H, Matei IR, Hoshino A, Kelsen D, Sagi I, Scherz A, Scherz-Shouval R, Yarden Y, Oren M, Egeblad M, Lewis JS, Keshari K, Grandgenett PM, Hollingsworth MA, Rajasekhar VK, Healey JH, Björnsson B, Simeone DM, Tuveson DA, Iacobuzio-Donahue CA, Bromberg J, Vincent CT, O'Reilly EM, DeMatteo RP, Balachandran VP, D'Angelica MI, Kingham TP, Allen PJ, Simpson AL, Elemento O, Sandström P, Schwartz RE, Jarnagin WR, Lyden D
Nat Med 2024 Aug;30(8):2170-2180. Epub 2024 Jun 28 doi: 10.1038/s41591-024-03075-7. PMID: 38942992Free PMC Article
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Thévenot T, Charon-Barra C, Calame P
Gastroenterology 2020 Apr;158(5):1222-1223. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.045. PMID: 31945359
Fournier JB, Testa EJ
N Engl J Med 2019 Jun 20;380(25):e48. doi: 10.1056/NEJMicm1804137. PMID: 31216402
Helmick RA, McMenomy BP, Huebert RC
Clin Gastroenterol Hepatol 2016 Jan;14(1):A39-40. Epub 2015 Sep 15 doi: 10.1016/j.cgh.2015.09.006. PMID: 26385443

Therapy

Ramdhani K, Lam MGEH, Braat AJAT, Smits MLJ, El-Haddad G
PET Clin 2024 Jul;19(3):431-446. doi: 10.1016/j.cpet.2024.03.010. PMID: 38816137
Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Puijk RS, Ruarus AH, Vroomen LGPH, van Tilborg AAJM, Scheffer HJ, Nielsen K, de Jong MC, de Vries JJJ, Zonderhuis BM, Eker HH, Kazemier G, Verheul H, van der Meijs BB, van Dam L, Sorgedrager N, Coupé VMH, van den Tol PMP, Meijerink MR; COLLISION Trial Group
BMC Cancer 2018 Aug 15;18(1):821. doi: 10.1186/s12885-018-4716-8. PMID: 30111304Free PMC Article
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article

Prognosis

Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KE, Hanna S, Askan G, Burman J, Ravichandran H, Zheng J, Jolissaint JS, Srouji R, Song Y, Choubey A, Kim HS, Cioffi M, van Beek E, Sigel C, Jessurun J, Velasco Riestra P, Blomstrand H, Jönsson C, Jönsson A, Lauritzen P, Buehring W, Ararso Y, Hernandez D, Vinagolu-Baur JP, Friedman M, Glidden C, Firmenich L, Lieberman G, Mejia DL, Nasar N, Mutvei AP, Paul DM, Bram Y, Costa-Silva B, Basturk O, Boudreau N, Zhang H, Matei IR, Hoshino A, Kelsen D, Sagi I, Scherz A, Scherz-Shouval R, Yarden Y, Oren M, Egeblad M, Lewis JS, Keshari K, Grandgenett PM, Hollingsworth MA, Rajasekhar VK, Healey JH, Björnsson B, Simeone DM, Tuveson DA, Iacobuzio-Donahue CA, Bromberg J, Vincent CT, O'Reilly EM, DeMatteo RP, Balachandran VP, D'Angelica MI, Kingham TP, Allen PJ, Simpson AL, Elemento O, Sandström P, Schwartz RE, Jarnagin WR, Lyden D
Nat Med 2024 Aug;30(8):2170-2180. Epub 2024 Jun 28 doi: 10.1038/s41591-024-03075-7. PMID: 38942992Free PMC Article
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Fournier JB, Testa EJ
N Engl J Med 2019 Jun 20;380(25):e48. doi: 10.1056/NEJMicm1804137. PMID: 31216402
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article
Gillams AR
Br J Radiol 2004 Sep;77(921):713-23. doi: 10.1259/bjr/86761907. PMID: 15447955

Clinical prediction guides

Mendiratta-Lala M, Wiggermann P, Pech M, Serres-Créixams X, White SB, Davis C, Ahmed O, Parikh ND, Planert M, Thormann M, Xu Z, Collins Z, Narayanan G, Torzilli G, Cho C, Littler P, Wah TM, Solbiati L, Ziemlewicz TJ
Radiology 2024 Sep;312(3):e233051. doi: 10.1148/radiol.233051. PMID: 39225612Free PMC Article
Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KE, Hanna S, Askan G, Burman J, Ravichandran H, Zheng J, Jolissaint JS, Srouji R, Song Y, Choubey A, Kim HS, Cioffi M, van Beek E, Sigel C, Jessurun J, Velasco Riestra P, Blomstrand H, Jönsson C, Jönsson A, Lauritzen P, Buehring W, Ararso Y, Hernandez D, Vinagolu-Baur JP, Friedman M, Glidden C, Firmenich L, Lieberman G, Mejia DL, Nasar N, Mutvei AP, Paul DM, Bram Y, Costa-Silva B, Basturk O, Boudreau N, Zhang H, Matei IR, Hoshino A, Kelsen D, Sagi I, Scherz A, Scherz-Shouval R, Yarden Y, Oren M, Egeblad M, Lewis JS, Keshari K, Grandgenett PM, Hollingsworth MA, Rajasekhar VK, Healey JH, Björnsson B, Simeone DM, Tuveson DA, Iacobuzio-Donahue CA, Bromberg J, Vincent CT, O'Reilly EM, DeMatteo RP, Balachandran VP, D'Angelica MI, Kingham TP, Allen PJ, Simpson AL, Elemento O, Sandström P, Schwartz RE, Jarnagin WR, Lyden D
Nat Med 2024 Aug;30(8):2170-2180. Epub 2024 Jun 28 doi: 10.1038/s41591-024-03075-7. PMID: 38942992Free PMC Article
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138. Epub 2020 Jun 11 doi: 10.1038/s41586-020-2394-6. PMID: 32528174
Machado MAC, Surjan RC, Makdissi F
Ann Surg Oncol 2020 Apr;27(4):1174-1179. Epub 2019 Nov 4 doi: 10.1245/s10434-019-08027-x. PMID: 31686346
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518

Recent systematic reviews

O'Connor S, Vercell A, Wong D, Yorke J, Fallatah FA, Cave L, Anny Chen LY
Eur J Oncol Nurs 2024 Feb;68:102510. Epub 2024 Jan 14 doi: 10.1016/j.ejon.2024.102510. PMID: 38310664
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Huang DQ, Tan DJH, Ng CH, Amangurbanova M, Sutter N, Lin Tay PW, Lim WH, Yong JN, Tang A, Syn N, Muthiah MD, Tan EXX, Dave S, Tay B, Majzoub AM, Gerberi D, Kim BK, Loomba R
Clin Gastroenterol Hepatol 2023 May;21(5):1169-1177. Epub 2022 Aug 5 doi: 10.1016/j.cgh.2022.06.032. PMID: 35940513Free PMC Article
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M
Cochrane Database Syst Rev 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3. PMID: 32118296Free PMC Article

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