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| Status |
Public on Jul 01, 2017 |
| Title |
Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution [ChIP-seq] |
| Organisms |
Drosophila melanogaster; Drosophila simulans |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We study the relatively unexplored evolutionary consequences of the epigenetic effects of transpoable elements (TEs) by providing the first genome-wide quantification of such effects in wild-derived D. melanogaster and D. simulans strains. Surprisingly, over half of euchromatic TEs show spread of repressive epigenetic marks to nearby DNA, resulting in differential epigenetic states of homologous genic alleles and, in return, selection against TEs. Interestingly, compared to D. melanogaster, the lower TE content in D. simulans is correlated with stronger epigenetic effects of TEs and higher levels of host genetic factors known to promote epigenetic silencing. We conclude that the epigenetic effects of euchromatic TEs, and host genetic factors modulating such effects, play a critical role in the population dynamics of TEs within and between species.
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| Overall design |
Examine the epigenetic effects of transposable elements
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| |
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| Contributor(s) |
Lee GY, Karpen GH |
| Citation(s) |
28695823 |
| |
| Submission date |
Feb 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Grace Yuh Chwen Lee |
| E-mail(s) |
[email protected]
|
| Organization name |
University of California, Irvine
|
| Street address |
UCI
|
| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92617 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL13304 |
Illumina HiSeq 2000 (Drosophila melanogaster) |
| GPL13306 |
Illumina HiSeq 2000 (Drosophila simulans) |
|
| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE94742 |
Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution |
|
| Relations |
| BioProject |
PRJNA373899 |
| SRA |
SRP099156 |
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