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| Status |
Public on Feb 16, 2018 |
| Title |
AAV-mediated RNAi of traumatic brain injury-induced genes in the rat hippocampus |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
To address the hypothesis that silencing deleterious or protective injury-induced genes in the rat hippocampus will reduce or increase the numbers of injured hippocampal neurons, alter cellular pathways essential for neuronal function and improve or worsen functional outcome after traumatic brain injury (TBI), we evaluated the effects of silencing neuronal nitric oxide synthase (nNOS) and glutathione peroxidase-1 (GPx-1) expression in the injured rat hippocampus.
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| Overall design |
Two weeks post-TBI/post-AAV treatment, hippocampal pyramidal neurons were laser captured for comparative whole genome microarray analysis.
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| Contributor(s) |
Boone DK, Crookshanks JM, Falduto MT, Torres KE, Hellmich HL |
| Citation(s) |
29016640 |
| |
| Submission date |
Dec 13, 2016 |
| Last update date |
Feb 16, 2018 |
| Contact name |
Michael Falduto |
| E-mail(s) |
[email protected]
|
| Phone |
847-291-9602
|
| Organization name |
GenUs BioSystems, Inc.
|
| Street address |
1808 Janke, Unit M
|
| City |
Northbrook |
| State/province |
IL |
| ZIP/Postal code |
60062 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14746 |
Agilent-028282 Whole Rat Genome Microarray 4x44K v3 (Probe Name version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA357551 |
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