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| Status |
Public on Jul 31, 2017 |
| Title |
Podocyte-specific JAK2 Overexpression Worsens Diabetic Kidney Disease in Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Overexpression of glomerular JAK2 mRNA specifically in glomerular podocytes of 129S6 mice led to significant increases in albuminuria, mesangial expansion, glomerulosclerosis, glomerular fibronectin accumulation, and glomerular basement membrane thickening as well as a significant reduction in podocyte density in diabetic mice. Treatment with a specific JAK1/2 inhibitor partly reversed the major phenotypic changes of DKD
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| Overall design |
Glomerular RNA was extracted using the RNeasy Mini Kit and processed for hybridization on Affymetrix Mouse Gene 2.1 ST chip microarrays
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| Contributor(s) |
Zhang H, Nair V, Saha J, Atkins KB, Wallace R, Hodgin JB, Saunders TL, Leiter EH, Myers MG, Werner T, Kretzler M, Brosius FC |
| Citation(s) |
28554737 |
| |
| Submission date |
Aug 31, 2016 |
| Last update date |
Mar 08, 2018 |
| Contact name |
Viji Nair |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Michigan
|
| Street address |
1152 West Medical Centre Dr.
|
| City |
Ann Arbor |
| ZIP/Postal code |
48331 |
| Country |
USA |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (10)
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| GSM2300044 |
glomeruli from JAK2 Akita diabetic glomeruli + vehicle 1 |
| GSM2300045 |
glomeruli from JAK2 Akita diabetic glomeruli + vehicle 2 |
| GSM2300046 |
glomeruli from JAK2 Akita diabetic glomeruli + vehicle 3 |
| GSM2300047 |
glomeruli from JAK2 Akita diabetic glomeruli + vehicle 4 |
| GSM2300048 |
glomeruli from JAK2 Akita diabetic glomeruli + vehicle 5 |
| GSM2300049 |
glomeruli from JAK2 Akita diabetic glomeruli + JAK1/2 inhibitor 1 |
| GSM2300050 |
glomeruli from JAK2 Akita diabetic glomeruli + JAK1/2 inhibitor 2 |
| GSM2300051 |
glomeruli from JAK2 Akita diabetic glomeruli + JAK1/2 inhibitor 3 |
| GSM2300052 |
glomeruli from JAK2 Akita diabetic glomeruli + JAK1/2 inhibitor 4 |
| GSM2300053 |
glomeruli from JAK2 Akita diabetic glomeruli + JAK1/2 inhibitor 5 |
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| Relations |
| BioProject |
PRJNA341474 |
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