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| Status |
Public on Mar 22, 2016 |
| Title |
MicroRNA expression profiling of CCl4-induced liver fibrosis in Mus musculus |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
To investigate the differences in microRNA expression profiles between fibrotic and normal livers, we performed microRNA microarrays for total RNA extracts isolated from mouse livers treated with carbontetrachloride (CCl4) or corn-oil for 10 weeks (n=3/group). MicroRNAs were considered to have significant differences in expression level when the expression difference showed more than two-fold change between the experimental and control groups at p<0.05. We found that 12 miRNAs were differentially expressed in CCl4-induced fibrotic liver.
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| Overall design |
To induce chronic liver fibrosis, seven-week-old mice received 0.6 ml/kg body weight of carbon-tetrachloride (CCl4) dissolved in corn-oil by intraperitoneal (i.p.) injection, twice a week for 10 weeks (n=3). As a control, same number of mice was injected with equal volume of corn-oil for 10 weeks.
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| Contributor(s) |
Hyun J, Jung Y |
| Citation(s) |
27322257 |
| |
| Submission date |
Jan 27, 2016 |
| Last update date |
Sep 27, 2016 |
| Contact name |
Jeongeun Hyun |
| E-mail(s) |
[email protected]
|
| Phone |
82-51-510-3894
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| Organization name |
Pusan National University
|
| Street address |
Pusandaehak-ro 63-beon gil
|
| City |
Pusan |
| ZIP/Postal code |
609-735 |
| Country |
South Korea |
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| Platforms (1) |
| GPL17912 |
Agilent-046065 Mouse_miRNA_V19.0_Microarray (miRNA ID version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA309936 |
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