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| Status |
Public on Jan 26, 2016 |
| Title |
Cortex PS2 APP transgenic mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene Expression profiles from whole cortical tissue from the PS2APP transgenic mouse model of Alzheimer's disease will reflect the cellular alterations, including the pathological drivers and the compensatory mechanisms of neurodegeneration when compared to wild-type control animals.
The "SAMID" sample characteristic is a sample identifier internal to Genentech.
The ID of this project in Genentech's ExpressionPlot database is PRJ0006684
Keywords: Expression profiling by array
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| Overall design |
5 Male transgenic and 5 Male wild-type mice were perfused and sacrificed at 3 months (earliest behavioral changes), 7 months (inflammation and plaque pathology), or 13 months (spreading synapse loss) of age. Hemicortices were subdissected and flash frozen prior to RNA extraction using the RNeasy Lipid Tissue extraction kit with on-column Dnase digestion.
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| Contributor(s) |
Friedman B, Lauffer B, Hansen D |
| Citation(s) |
27097852 |
| |
| Submission date |
Nov 13, 2015 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Brad A Friedman |
| E-mail(s) |
[email protected]
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| Organization name |
Genentech, Inc.
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| Department |
Bioinformatics
|
| Street address |
1 DNA Way
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94133 |
| Country |
USA |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA302153 |
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