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| Status |
Public on Jul 01, 2015 |
| Title |
Myocardial gene expression in response to pressure overload |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Myocardial deletion of klf4 sensitizes mouse to pressure overload. In order to gain a better understanding of molecular mechanisms of such alterations, we profiled gene expression before and after 3-day of pressure overload (induced by transverse aortic constriction -TAC) in the hearts from MHC-cre (Cre) control and MHC-cre-klf4-deficient (KO) mice.
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| Overall design |
10wk old male mice was subjected to transverse aortic constriction (TAC) to induce pressure overload or sham operation as control group. After 3 days, heart was removed and total RNA was extracted from apex and subjected for array analysis. Four animals in each group.
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| Contributor(s) |
Liao X, Jain MK |
| Citation(s) |
26241060 |
| |
| Submission date |
Sep 05, 2014 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Mukesh Jain |
| Organization name |
Case Western Reserve University
|
| Street address |
2103 Cornell Rd
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44106 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA260410 |
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