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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 04, 2016 |
| Title |
Gene expression profile of splenic CD19 cells from NTg, PTPROt Tg, TCL1 Tg and PTPROt/TCL1 double Tg mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TCL1 is an an oncogene and transgenic (Tg) mice expressing TCL1 specifically in B-cells are well-characterized models for chronic lymphocytic leukemia. On the contrary, PTPROt is a phosphatase with tumor suppressor characteristics in many cancers including leukemia. Our hypothesis was that transgenic expression of PTPROt in the B-cells of TCL1 Tg mice will alleviate disease phenotype and allow the study of the in vivo mechanism of action of PTPROt. To test this we have generated Tg mice with B-cell specific expression of PTPROt and crossed these mice with the TCL1 Tg mice.
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| Overall design |
Single-channel experiment. Four replicates for each of the four groups (NTg, PTPROt Tg, TCL1 Tg, PTPROt/TCL1 double Tg) of mice at 4 months of age.
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| Contributor(s) |
Motiwala T, Mo X, Jacob ST |
| Citation(s) |
25482129 |
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| Submission date |
Aug 21, 2014 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Tasneem Motiwala |
| E-mail(s) |
[email protected]
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| Organization name |
The Ohio State University
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| Street address |
420 W. 12th Ave
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| City |
Columbus |
| ZIP/Postal code |
43210 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (16)
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| GSM1482860 |
NTg, biological replicate 4 |
| GSM1482861 |
PTPROt, biological replicate 1 |
| GSM1482862 |
PTPROt, biological replicate 2 |
| GSM1482863 |
PTPROt, biological replicate 3 |
| GSM1482864 |
PTPROt, biological replicate 4 |
| GSM1482865 |
TCL1, biological replicate 1 |
| GSM1482866 |
TCL1, biological replicate 2 |
| GSM1482867 |
TCL1, biological replicate 3 |
| GSM1482868 |
TCL1, biological replicate 4 |
| GSM1482869 |
PTPROt/TCL1, biological replicate 1 |
| GSM1482870 |
PTPROt/TCL1, biological replicate 2 |
| GSM1482871 |
PTPROt/TCL1, biological replicate 3 |
| GSM1482872 |
PTPROt/TCL1, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA258585 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE60582_RAW.tar |
64.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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