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Series GSE46602 Query DataSets for GSE46602
Status Public on Jul 01, 2015
Title Expression data from prostate cancer and benign prostate glands
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Prostate cancer is a leading cause of cancer death amongst males. The main clinical dilemma in treating prostate cancer is the high number of indolent cases that confer a significant risk of over diagnosis and over treatment. In this study we have performed a genome expression profiling of tumor tissue specimens from 36 patients with prostate cancer to identify transcripts that delineate aggressive and indolent cancer. We included normal prostate biopsies from 14 patients in our analysis. Unsupervised hierarchical cluster analysis separated the cancer samples into two groups with a significant overrepresentation of tumors from patients with biochemical recurrence in one of the groups (Chi2, p=0.02). The samples were separated by basically three clusters of genes that showed differential expression between the two sample clusters - totaling 371 transcripts. Ingenuity Pathway Analysis revealed that one cluster contained genes associated with invasive properties of the tumor, another genes associated with the cell cycle, and the last cluster genes involved in several biological functions. We successfully validated the transcripts association with recurrence using two publicly available patient datasets totaling 669 patients. Twelve genes were found to be independent predictors of recurrence in multivariate logistical regression analysis.
 
Overall design In this study we have performed a genome expression profiling of tumor tissue specimens from 36 patients with prostate cancer to identify transcripts that delineate aggressive and indolent cancer. We included normal prostate biopsies from 14 patients in our analysis.
 
Contributor(s) Mortensen MM, Dyrskjøt L
Citation(s) 26522007
Submission date May 02, 2013
Last update date Mar 25, 2019
Contact name Martin Mørck Mortensen
E-mail(s) [email protected]
Organization name Aarhus University Hospital
Department Dept. of Urology
Street address Brendstrupgaardsvej 100
City Aarhus N
ZIP/Postal code DK-8200
Country Denmark
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (50)
GSM1133136 Prostate cancer cells, PC0168
GSM1133137 Prostate cancer cells, PC0171
GSM1133138 Prostate cancer cells, PC0172
Relations
BioProject PRJNA201060

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46602_RAW.tar 229.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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