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| Status |
Public on Oct 27, 2012 |
| Title |
Gene expression analysis after selective expression of tissue factor isoforms |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of TF isoform-induced breast cancer cell transformation at gene expression level. The hypothesis tested in the present study was that expression of TF isoforms upregulate genes involved in proliferation and transformation, while downregulating genes involved in cell cycle arrest and apoptosis. Results provide important information on the cellular response to TF expression with respect to pro-oncogenic programs .
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| Overall design |
Total RNA obtained from an MCF-7-based cell model (2A3-3) expressing full length tissue factor (2A3-3-flTF) or alternatvively spliced tissue factor (2A3-3-asTF) compared to cells expressing an empty vector control (2A3-3-pcDNA).
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| |
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| Contributor(s) |
Kocatürk B, Versteeg H |
| Citation(s) |
23801760 |
| |
| Submission date |
Oct 26, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Henri H Versteeg |
| E-mail(s) |
[email protected]
|
| Phone |
+31-71-5263872
|
| Organization name |
Leiden University Medical Center
|
| Department |
Einthoven Lab for Experimental Vascular Medicine
|
| Street address |
Albinusdreef 2
|
| City |
Leiden |
| ZIP/Postal code |
2333 ZA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA178362 |
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