|
| Status |
Public on Sep 21, 2012 |
| Title |
Tag-seq in eye-antennal and wing imaginal discs of D.melanogaster, D.yakuba, and D.virilis; RNA-seq in wild-type and glass mutant D.melanogaster eye-antennal imaginal discs. |
| Organisms |
Drosophila melanogaster; Drosophila virilis; Drosophila yakuba |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study we use Tag-sequencing in eye-antennal and wing imaginal discs across Drosophila species to determine a set of conserved eye-specific developmental genes. Next, we perform motif discovery analysis using the tool i-cisTarget, to depict the core gene developmental network underlying compound eye photoreceptor. The Glass position weight matrix appears as the most highly overrepresented motif, thus positioning Glass as a master regulator in compound eye photoreceptor development. Differential gene expression analysis by RNA-seq in D.melanogaster wild-type eye-antennal versus glass mutant [gl 60j] shows that the majority of our predicted Glass targets show strong downregulation in the glass mutant.
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series.
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| Citation(s) |
23070853 |
| |
| Submission date |
Jul 31, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Stein Aerts |
| Organization name |
KULeuven
|
| Department |
Center for Human Genetics
|
| Lab |
Laboratory of Computational Biology
|
| Street address |
Herestraat 49
|
| City |
Leuven |
| ZIP/Postal code |
3000 |
| Country |
Belgium |
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| Platforms (4)
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| GPL11203 |
Illumina Genome Analyzer IIx (Drosophila melanogaster) |
| GPL13304 |
Illumina HiSeq 2000 (Drosophila melanogaster) |
| GPL15872 |
Illumina Genome Analyzer IIx (Drosophila yakuba) |
| GPL15873 |
Illumina Genome Analyzer IIx (Drosophila virilis) |
|
| Samples (10)
|
| GSM978987 |
RNA_seq_eye-antennal_imaginal_disc_wild-type [CantonS] |
| GSM978988 |
RNA_seq_eye-antennal_imaginal_disc_wild-type [RAL-208] |
| GSM978989 |
RNA_seq_eye-antennal_imaginal_disc_gl[60j]_rep1 |
| GSM978990 |
RNA_seq_eye-antennal_imaginal_disc_gl[60j]_rep2 |
| GSM978991 |
Tag_seq_eye-antennal_imaginal_disc_D.melanogaster |
| GSM978992 |
Tag_seq_wing_imaginal_disc_D.melanogaster |
| GSM978993 |
Tag_seq_eye-antennal_imaginal_disc_D.yakuba |
| GSM978994 |
Tag_seq_wing_imaginal_disc_D.yakuba |
| GSM978995 |
Tag_seq_eye-antennal_imaginal_disc_D.virilis |
| GSM978996 |
Tag_seq_wing_imaginal_disc_D.virilis |
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| This SuperSeries is composed of the following SubSeries: |
| GSE39781 |
RNA-seq in wild-type and glass mutant eye-antennal discs in Drosophila melanogaster |
| GSE39782 |
Tag-seq profiling in eye-antennal and wing imaginal discs of D. melanogaster, D. yakuba and D. virilis |
|
| Relations |
| BioProject |
PRJNA171883 |
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