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Series GSE33022 Query DataSets for GSE33022
Status Public on Sep 01, 2017
Title Cardiac aldosterone and corticosterone regulated genes in mice with cardiomyocytes targeted mineralocorticoid receptor overexpression (MR-Cardio mice) and their controls (Ctrl mice)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. MR binds aldosterone, but also glucocorticoids; the identity of the ligand responsible for the deleterious effects of cardiac MR activation is still unclear. Mice overexpressing MR in cardiomyocytes (MR-Cardio) and their controls (Ctrl) were treated for 7 days with aldosterone or corticosterone and a whole genome microarray analysis was performed.
 
Overall design Six-group experiment: Control mice (Ctrl), transgenic mice (MR-Cardio), Ctrl mice + aldosterone treatment, MR-Cardio mice + aldosterone treatment, Ctrl mice + corticosterone treatment, MR-Cardio mice + corticosterone treatment. Five comparisons: Ctrl vs MR-Cardio, Ctrl vs Ctrl-Aldo, Ctrl vs Ctrl-Cortico, MR-Cardio vs MR-Cardio-Aldo, MR-Cardio vs MR-Cardio-Cortico
 
Contributor(s) Messaoudi S, Pelloux V
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Submission date Oct 17, 2011
Last update date Nov 01, 2017
Contact name Smail Messaoudi
E-mail(s) [email protected]
Phone +1 613 562 5800
Organization name University of Ottawa
Department BMI
Street address 451 smyth road
City Ottawa
State/province Ontario
ZIP/Postal code K1H 8M5
Country Canada
 
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (34)
GSM818510 Heart Ctrl no treatment sample 1 (mouse n° 210)
GSM818511 Heart Ctrl no treatment sample 2 (mouse n° 217)
GSM818512 Heart Ctrl no treatment sample 3 (mouse n° 223)
Relations
BioProject PRJNA148021

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33022_RAW.tar 354.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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