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| Status |
Public on Oct 10, 2010 |
| Title |
Effect of Imatinib on chronic myelogenous leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which is present in almost every patient with chronic myeloid leukemia. In this study, the tyrosine kinase inhibitor Imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of CML cell lines were analyzed in response to Imatinib treatment.
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| Overall design |
Three CML cell lines (KU-812, KCL-22, JURL-MK1) were either treated with 10 µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571.
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| Contributor(s) |
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon S, Nahar R, Braig M, Park E, Kim Y, Hofmann W, Herzog S, Jumaa H, Koeffler PH, Yu JJ, Heisterkamp N, Wu H, Ye HB, Melnick A, Müschen M |
| Citation(s) |
21593872, 21911423 |
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| Submission date |
Oct 03, 2010 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Markus Müschen |
| E-mail(s) |
[email protected]
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| Phone |
+ 1 323 361 5592
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| Fax |
+1 323 361 1516
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| URL |
http://www.lymphocytes.de/
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| Organization name |
University of Southern California
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| Department |
Childrens Hospital Los Angeles
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| Lab |
Müschen Lab
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| Street address |
4650 Sunset Blvd
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA132497 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24493_RAW.tar |
28.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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