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| Status |
Public on Mar 31, 2023 |
| Title |
METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling (RNA-Seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the effect of METTL3 function in the regulation of neutrophil activation, we established neutrophil METTL3 knock out mice by crossing METTL3flox/flox mice with Lyzm-cre mice.
We then performed gene expression profiling analysis using data obtained from RNA-seq of isolated neutrophil from METTL3f/f and METTL3f/f Lyzm-Cre mice with or without intraperitoneal injection of lipopolysaccharide (LPS) treatment.
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| |
|
| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for METTL3flox/flox neutrophil and METTL3flox/flox-Lyzmcre neutrophil.
|
| Web link |
http://10.1016/j.celrep.2023.112259
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| |
|
| Contributor(s) |
Luo S, Tang J |
| Citation(s) |
36920907 |
| |
| Submission date |
Feb 12, 2023 |
| Last update date |
Jun 30, 2023 |
| Contact name |
Shuhua Luo |
| E-mail(s) |
[email protected]
|
| Organization name |
Guangdong Medical University
|
| Street address |
2 Wenming East Roadan
|
| City |
Zhanjiang |
| State/province |
guangdong |
| ZIP/Postal code |
524000 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE225143 |
METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling |
|
| Relations |
| BioProject |
PRJNA934079 |
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