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| Status |
Public on Jun 29, 2022 |
| Title |
Analysis of exosomal cargo provides accurate clinical, histologic and mutational information in non-small cell lung cancer. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Despite advances in the understanding of lung cancer biology and the development of new drugs, most cases of lung cancer are diagnosed at an advanced stages. The present study is a proof of concept with the main aim of implementing the use of exosomes as a minimal invasive platform to search new biomarkers and determine tumor features in NSCLC.
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| Overall design |
Gene expression was analysed in tumor-derived exosomes secreted by cell lines and primary cultures grown under different conditions, comparing between LUAD and LUSC; and adherent cells (2D) vs spheroids (3D). Two replicates were analyzed per each group.
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| Contributor(s) |
Duréndez-Sáez E, Calabuig-Fariñas S, Torres-Martínez S, Moreno-Manuel A, Herreros-Pomares A, Escorihuela E, Mosqueda M, Gallach S, Guijarro R, Serna E, Suárez-Cabrera C, Paramio J, Blasco A, Camps C, Jantus-Lewintre E |
| Citation(s) |
35804987 |
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| Submission date |
Mar 09, 2022 |
| Last update date |
Apr 07, 2023 |
| Contact name |
Cristian Suarez Cabrera |
| E-mail(s) |
[email protected]
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| Phone |
+34 699044222
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| Organization name |
CIEMAT
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| Lab |
Molecular Oncology Unit
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| Street address |
Av. Complutense 40
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| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28040 |
| Country |
Spain |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA814254 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE198238_RAW.tar |
523.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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