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| Status |
Public on Apr 17, 2021 |
| Title |
Reprogramming the spleen into a functioning “liver” in vivo I |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We restored liver function in the spleen by direct reprogramming splenic fibroblasts in situ and thereby transformed the spleen into a “liver” with sufficient physiological functions within a living animal.
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| Overall design |
The Gene Expression profiling of PBS-treated spleens (PBS) vs SiO2-remodelled spleens (SiO2), PBS as control; primary mouse SiO2-remodelled spleen fibroblasts (MF) vs hepatocyte-like cells (iHep) vs primary hepatocytes (PH), MF as control; SiO2-treated spleens (SiO2) vs SiO2-3TF-3C-treated spleen (hepatized spleens) vs normal liver tissues, SiO2 as control.Five cell/spleen samples were pooled according to individual groups.
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| Contributor(s) |
Dong L, Wang C, Zhang J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 16, 2021 |
| Last update date |
Apr 18, 2021 |
| Contact name |
Chunyan Liu |
| E-mail(s) |
[email protected]
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| Organization name |
Nanjing University
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| Street address |
163 Xianlin Avenue
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| City |
Nanjing |
| ZIP/Postal code |
210093 |
| Country |
China |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE172245 |
Reprogramming the spleen into a functioning “liver” in vivo |
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| Relations |
| BioProject |
PRJNA722516 |
