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Series GSE171991 Query DataSets for GSE171991
Status Public on Jul 19, 2021
Title Gene expression in non-perfused liver samples from endotoxemic Sus scrofa in context of deoxynivalenol contaminated diets
Organism Sus scrofa
Experiment type Expression profiling by array
Summary It has been proposed that chronic exposure to deoxynivalenol modulates hepatic gene expression and that sensivity to xenobiotics like deoxynivalenol is modulated by inflammation.
We used microarrays to evaluate whether chronic deoxynivalenol exposure influences the hepatic gene expression of Sus scrofa in vivo and whether interaction between chronic deoxynivalenol exposure and systemic inflammation occur.
 
Overall design Sus scrofa liver samples were collected at slaugthering 195 minutes after inducing endotoxemia via pre-hepatic or post-hepatic LPS infusion. Animals were subjected to chronic deoxynivalenol exposure via diet (4.59 mg deoxynivalenol/kg diet) or to a control diet (0.12 mg deoxynivalenol/kg diet) for 29 days before LPS infusions. RNA of nin-perfused liver samples was isolated and subjected to Affymetrix microarrays
 
Contributor(s) Bühler S, Oster M, Heymann A, Billenkamp F
Citation(s) 34338001
Submission date Apr 13, 2021
Last update date Sep 14, 2021
Contact name Fabian Billenkamp
Organization name Friedrich-Loeffler-Institute
Street address Bundesallee 37
City Braunschweig
ZIP/Postal code 38116
Country Germany
 
Platforms (1)
GPL16569 [SNOWBALLs520824F] Affymetrix Porcine Snowball Array
Samples (43)
GSM5239444 control diet, pre-hepatic and post-hepatic infusion with NaCL, biological rep 1
GSM5239445 control diet, pre-hepatic infusion with NaCl and post-hepatic infusion with LPS, biological rep 1
GSM5239446 Deoxynivalenol contaminated diet, pre-hepatic and post-hepatic infusion with NaCL, biological rep 1
Relations
BioProject PRJNA721658

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE171991_RAW.tar 167.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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