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| Status |
Public on Nov 19, 2020 |
| Title |
Relationship between insulin sensitivity and gene expression in human skeletal muscle |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this study was therefore to investigate molecular mechanisms associated with insulin sensitivity in skeletal muscle by relating global skeletal muscle gene expression with a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR). To identify genes with skeletal muscle expression related to insulin sensitivity, we obtained muscle biopsies from 38 non-diabetic participants in study A. We then profiled muscle gene expression using Affymetrix oligonucleotide microarrays (Affymetrix Custom Array NuGO-Hs1a520180 GeneChip). To replicate the findings from study A, we included 9 non-diabetic participants from study B. We performed skeletal muscle gene expression profiling from these participants using the Agilent oligonucleotide microarrays (Agilent-G4112F (Feature Number version)). Insulin sensitivity was estimated using the 1/HOMA-IR method calculated from the oral glucose tolerance test (OGTT) values.
This SuperSeries is composed of the SubSeries listed below.
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|
| Overall design |
The aim of this study was therefore to investigate molecular mechanisms associated with insulin sensitivity in skeletal muscle by relating global skeletal muscle gene expression with a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR).
Refer to individual Series
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| |
|
| Citation(s) |
22547424, 26338460, 20739510, 33639916 |
| |
| Submission date |
Nov 18, 2020 |
| Last update date |
Mar 11, 2021 |
| Contact name |
Hemang Mahendrakumar Parikh |
| Organization name |
University of South Florida
|
| Department |
Health Informatics Institute
|
| Street address |
3650 Spectrum Blvd.
|
| City |
Tampa |
| State/province |
FL |
| ZIP/Postal code |
33612 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
| GPL7144 |
NuGO array (human) NuGO_Hs1a520180 [CDF: Hs_ENTREZG_10] |
|
| Samples (47)
|
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| This SuperSeries is composed of the following SubSeries: |
| GSE161719 |
Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study A) |
| GSE161720 |
Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study B) |
|
| Relations |
| BioProject |
PRJNA679248 |
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