NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE157678 Query DataSets for GSE157678
Status Public on Jan 10, 2022
Title Comparison of RNA sequencing profiles in domed and flat colonies of ocular surface epithelial stem cells induced from human pluripotent stem cell
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary RNA-seq analysis revealed that genes associated with lacrimal gland development, such as BARX2, SIX1, SIX2, SOX9, and KRT15, were upregulated in domed colonies compared to flat colonies. In flat colonies, mucosal epithelial keratin, KRT13 and the corneal epithelial progenitor cell markers, CDH2 and NGFR were up-regulated, along with YAP1 and its downstream genes, CTGF and CYR61, which are involved in epithelial development.
 
Overall design RNA sequencing profiles of domed and flat colonies of ocular surface epithelial stem cells
 
Contributor(s) Okubo T, Hayashi R
Citation(s) 35444274
Submission date Sep 08, 2020
Last update date Apr 24, 2022
Contact name Toru Okubo
E-mail(s) [email protected]
Organization name Rohto Pharmaceutical
Department Basic Research Development Division
Lab Cell Technology Group
Street address 6-5-4 Kunimidai
City Kizugawa
State/province Kyoto
ZIP/Postal code 619-0216
Country Japan
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM4773182 Ocular surface epithelial stem cell F1
GSM4773183 Ocular surface epithelial stem cell F5
GSM4773184 Ocular surface epithelial stem cell F8
Relations
BioProject PRJNA662372
SRA SRP281604

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE157678_raw_counts.txt.gz 242.1 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap