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| Status |
Public on Feb 12, 2020 |
| Title |
JMJD1A inhibits proliferation and aggressiveness of gastric cancer by up-regulating RUNX3 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The histone demethylase JMJD1A（Jumoji domain containing 1A） is overexpressed in multiple cancers and promotes cancer progression. However, the role and mechanism of JMJD1A in gastric cancer remains poorly understood.Here, we found that JMJD1A could suppress gastric cancer cell proliferation, migration, invasion and xenograft tumor growth. Using RNA sequencing, we identified RUNX3 as a novel target gene of JMJD1A.
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| |
|
| Overall design |
Examination the total RNA change of JMJD1A depletion in SGC-7901 cells
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| |
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| Contributor(s) |
Ning K, Shao Y |
| Citation(s) |
32762126 |
| |
| Submission date |
Feb 11, 2020 |
| Last update date |
Oct 13, 2020 |
| Contact name |
Ke Ning |
| E-mail(s) |
[email protected]
|
| Organization name |
China Medial University
|
| Street address |
PuHe street No.77
|
| City |
ShenYang |
| State/province |
LiaoNing |
| ZIP/Postal code |
110122 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA606040 |
| SRA |
SRP248223 |
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