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| Status |
Public on Sep 07, 2019 |
| Title |
miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants. |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
To further understanding of miRNA expression during radioprotectation, we used microarray analysis to determine the differential expression of miRNAs in the bone marrow of mice exposed to high-dose IR with and without pretreatment with three types of radioprotectants: Amifostine (WR2721), CBLB502, and Nilestriol, as well in the hypothalamus of mice exposed to IR with and without pretreatment with amifostine. Overall, amifostine treatment led to a similar expression pattern of miRNAs to that of CBLB502 but not to that of nilestriol in bone marrow. The radioprotectants exhibited mostly opposite effects against IR-induced miRNAs. These results expand the biological function of miRNAs in mediating the activity of radioprotectants, further offering insights into the molecular mechanism underlying radioprotection.
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| Overall design |
Radiation induced miRNA expression in mice bone marrow and hypothalamus pretreated with amifostime, CBLB502 and nilestriol was measured at 12 hours after exposure to doses of 8 Gy gamma-rays. The bone marrow from three animals were pooled in one sample for each treatment.
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| Contributor(s) |
Ge C, Tian B, Fu H, Liu B, Zhu J, Zheng X |
| Citation(s) |
33117095 |
| |
| Submission date |
Sep 06, 2019 |
| Last update date |
Nov 02, 2020 |
| Contact name |
Changhui Ge |
| E-mail(s) |
[email protected], [email protected]
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| Organization name |
Beijing institute of Radiation Medicine
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| Department |
Department of Experimental Hematology and Biochemistry
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| Street address |
27 Taiping Rd., Haidian Dist.
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| City |
Beijing |
| ZIP/Postal code |
100850 |
| Country |
China |
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| Platforms (1) |
| GPL17912 |
Agilent-046065 Mouse_miRNA_V19.0_Microarray (miRNA ID version) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE137013 |
Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants |
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| Relations |
| BioProject |
PRJNA564280 |
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