 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Mar 19, 2020 |
| Title |
Systemic approaches reveal anti-adipogenic signals at the onset of obesity–related inflammation in white adipose tissue [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
HFD feeding induces a rapid adipocyte progenitors (APs) proliferation in visceral adipose tissue (vWAT), followed by a block of differentiation. In contrast, subcutaneous adipose tissue (scWAT), in obesity, undergoes trans-differentiation of beige adipocytes to white and, consequently, a hyperplastic growth at later stages. We performed RNA-seq to investigate the global transcriptomic changes induced by HFD feeding
|
| |
|
| Overall design |
We had 6 experimental conditions in C67Bl/6 mice: 1) mice fed with CTR diet for 1 week, 2) mice fed with HFD diet for 1 week, 3) mice fed with CTR diet for 8 weeks, 4) mice fed with HFD diet for 1 week, 5) mice fed with CTR diet for 20 weeks, 6) mice fed with HFD diet for 20 weeks. For all the experimental group we analyzed both vWAT and scWAT with 2 biological replicate per condition.
|
| |
|
| Contributor(s) |
Caputo T, Tran VD, Bararpour N, Gilardi F, Desvergne B |
| Citation(s) |
32178738 |
| |
| Submission date |
Jun 13, 2019 |
| Last update date |
Jun 18, 2020 |
| Contact name |
Richard Coward |
| Organization name |
Bristol Royal hospital for Sick Children & University of Bristol
|
| Department |
Bristol Medical School
|
| Street address |
Dorothy Hodgkin Building, Whitson Street, Bristol
|
| City |
Lausanne |
| ZIP/Postal code |
BS1 3NY |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (72)
|
| GSM3889226 |
vWAT, 1 week, control, rep 4 |
| GSM3889227 |
vWAT, 1 week, control, rep 5 |
| GSM3889228 |
vWAT, 1 week, control, rep 6 |
| GSM3889229 |
vWAT, 1 week, high fat diet, rep 1 |
| GSM3889230 |
vWAT, 1 week, high fat diet, rep 2 |
| GSM3889231 |
vWAT, 1 week, high fat diet, rep 3 |
| GSM3889232 |
vWAT, 1 week, high fat diet, rep 4 |
| GSM3889233 |
vWAT, 1 week, high fat diet, rep 5 |
| GSM3889234 |
vWAT, 1 week, high fat diet, rep 6 |
| GSM3889235 |
scWAT, 1 week, control, rep 1 |
| GSM3889236 |
scWAT, 1 week, control, rep 2 |
| GSM3889237 |
scWAT, 1 week, control, rep 3 |
| GSM3889238 |
scWAT, 1 week, control, rep 4 |
| GSM3889239 |
scWAT, 1 week, control, rep 5 |
| GSM3889240 |
scWAT, 1 week, control, rep 6 |
| GSM3889241 |
scWAT, 1 week, high fat diet, rep 1 |
| GSM3889242 |
scWAT, 1 week, high fat diet, rep 2 |
| GSM3889243 |
scWAT, 1 week, high fat diet, rep 3 |
| GSM3889244 |
scWAT, 1 week, high fat diet, rep 4 |
| GSM3889245 |
scWAT, 1 week, high fat diet, rep 5 |
| GSM3889246 |
scWAT, 1 week, high fat diet, rep 6 |
| GSM3889247 |
vWAT, 8 weeks, control, rep 1 |
| GSM3889248 |
vWAT, 8 weeks, control, rep 2 |
| GSM3889249 |
vWAT, 8 weeks, control, rep 3 |
| GSM3889250 |
vWAT, 8 weeks, control, rep 4 |
| GSM3889251 |
vWAT, 8 weeks, control, rep 5 |
| GSM3889252 |
vWAT, 8 weeks, control, rep 6 |
| GSM3889253 |
vWAT, 8 weeks, high fat diet, rep 1 |
| GSM3889254 |
vWAT, 8 weeks, high fat diet, rep 2 |
| GSM3889255 |
vWAT, 8 weeks, high fat diet, rep 3 |
| GSM3889256 |
vWAT, 8 weeks, high fat diet, rep 4 |
| GSM3889257 |
vWAT, 8 weeks, high fat diet, rep 5 |
| GSM3889258 |
vWAT, 8 weeks, high fat diet, rep 6 |
| GSM3889259 |
scWAT, 8 weeks, control, rep 1 |
| GSM3889260 |
scWAT, 8 weeks, control, rep 2 |
| GSM3889261 |
scWAT, 8 weeks, control, rep 3 |
| GSM3889262 |
scWAT, 8 weeks, control, rep 4 |
| GSM3889263 |
scWAT, 8 weeks, control, rep 5 |
| GSM3889264 |
scWAT, 8 weeks, control, rep 6 |
| GSM3889265 |
scWAT, 8 weeks, high fat diet, rep 1 |
| GSM3889266 |
scWAT, 8 weeks, high fat diet, rep 2 |
| GSM3889267 |
scWAT, 8 weeks, high fat diet, rep 3 |
| GSM3889268 |
scWAT, 8 weeks, high fat diet, rep 4 |
| GSM3889269 |
scWAT, 8 weeks, high fat diet, rep 5 |
| GSM3889270 |
scWAT, 8 weeks, high fat diet, rep 6 |
| GSM3889271 |
vWAT, 20 weeks, control, rep 1 |
| GSM3889272 |
vWAT, 20 weeks, control, rep 2 |
| GSM3889273 |
vWAT, 20 weeks, control, rep 3 |
| GSM3889274 |
vWAT, 20 weeks, control, rep 4 |
| GSM3889275 |
vWAT, 20 weeks, control, rep 5 |
| GSM3889276 |
vWAT, 20 weeks, control, rep 6 |
| GSM3889277 |
vWAT, 20 weeks, high fat diet, rep 1 |
| GSM3889278 |
vWAT, 20 weeks, high fat diet, rep 2 |
| GSM3889279 |
vWAT, 20 weeks, high fat diet, rep 3 |
| GSM3889280 |
vWAT, 20 weeks, high fat diet, rep 4 |
| GSM3889281 |
vWAT, 20 weeks, high fat diet, rep 5 |
| GSM3889282 |
vWAT, 20 weeks, high fat diet, rep 6 |
| GSM3889283 |
scWAT, 20 weeks, control, rep 1 |
| GSM3889284 |
scWAT, 20 weeks, control, rep 2 |
| GSM3889285 |
scWAT, 20 weeks, control, rep 3 |
| GSM3889286 |
scWAT, 20 weeks, control, rep 4 |
| GSM3889287 |
scWAT, 20 weeks, control, rep 5 |
| GSM3889288 |
scWAT, 20 weeks, control, rep 6 |
| GSM3889289 |
scWAT, 20 weeks, high fat diet, rep 1 |
| GSM3889290 |
scWAT, 20 weeks, high fat diet, rep 2 |
| GSM3889291 |
scWAT, 20 weeks, high fat diet, rep 3 |
| GSM3889292 |
scWAT, 20 weeks, high fat diet, rep 4 |
| GSM3889293 |
scWAT, 20 weeks, high fat diet, rep 5 |
| GSM3889294 |
scWAT, 20 weeks, high fat diet, rep 6 |
|
| This SubSeries is part of SuperSeries: |
| GSE132885 |
Systemic approaches reveal anti-adipogenic signals at the onset of obesity–related inflammation in white adipose tissue |
|
| Relations |
| BioProject |
PRJNA548796 |
| SRA |
SRP201385 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE132706_RAW.tar |
12.5 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...