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| Status |
Public on Feb 05, 2019 |
| Title |
Expression data from healthy and diastolic heart failure rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Heart failure (HF) with preserved ejection fraction (HFpEF) is rising, whose morbidity, mortality and healthcare costs are similar to HF with reduced ejection fraction (HFrEF). Although substantial molecular pathways lead to the changes in organ and tissue levels, there are still lack of successful treatments for HFpEF given the complexity molecular networks remaining unknown. Here we report that the significantly changed genes of HFpEF rats associates positively with inflammatory processes and immune responses while negatively with calcium ion transport into cytosol. GSEA analysis shows several KEGG pathways are significantly enriched in HFpEF rats including p53 signaling pathway, Toll like receptor signaling pathway and so on. Our study provides new insights into HFpEF pathogenesis and a new therapeutic against HFpEF.
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| Overall design |
Total RND of hearts from healthy and HFpEF rats was obtained, and RNA quantity and quality were measured by NanoDrop ND-1000. RNA microarray were performed.
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| Contributor(s) |
Zhang W, Yao W |
| Citation(s) |
32397533 |
| |
| Submission date |
Feb 04, 2019 |
| Last update date |
Jun 17, 2020 |
| Contact name |
Wenxi Zhang |
| E-mail(s) |
[email protected]
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| Organization name |
Peking University
|
| Street address |
No.5 Yiheyuan Road, Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
100871 |
| Country |
China |
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| Platforms (1) |
| GPL14746 |
Agilent-028282 Whole Rat Genome Microarray 4x44K v3 (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA520901 |
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