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| Status |
Public on Mar 05, 2019 |
| Title |
Mushroom body-specific RNA sequencing to examine the role of Bap60, a core SWI/SNF subunit, in the regulation of neuronal genes. |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing was used to identify genome wide transcriptional changes occurring in the Drosophila mushroom body in juvenile and mature adult flies expressing a mushroom body-specific RNAi knockdown of Bap60. The results of this analysis suggested a role for Bap60 in the regulation of neurodevelopmental genes during a critical time window of juvenile adult brain development.
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| Overall design |
RNA from mushroom body nuclei was sequenced from Drosophila melanogaster expressing a mushroom body-specific RNAi knockdown of Bap60 or mCherry (control) in both juvenile (2 and 3 replicates, respectively) and mature (5 replicates each) adult flies.
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| Contributor(s) |
Nixon KC, Kramer JM |
| Citation(s) |
30879640 |
| |
| Submission date |
Nov 23, 2018 |
| Last update date |
Jun 04, 2019 |
| Contact name |
Jamie M Kramer |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Western Ontario
|
| Department |
Physiology and Pharmacology
|
| Street address |
1151 Richmond St.
|
| City |
London |
| State/province |
Ontario |
| ZIP/Postal code |
N6A 3K7 |
| Country |
Canada |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA506716 |
| SRA |
SRP170457 |
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