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| Status |
Public on Feb 26, 2019 |
| Title |
Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome variation profiling by high throughput sequencing
|
| Summary |
We identified that downregulation of RNF20/H2Bub1 is involved in HGSOC progression through altering key immune signaling pathways.
The goal of ATAC-seq analysis was to profile chromatin conformation in FTSEC cells (FT190 and FT194 cell lines) with RNF20 knockdown (shRNF20) or control shRNA. The data generated by ATAC-Seq was integrated with RNA-seq data analysis for the same samples.
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| Overall design |
The mRNA profiles of FT190 and FT194 shRNF20 (RNF20 knockdown) or control shRNA cells were generated by RNA-Seq using Illumina HiSeq 2500, in triplicates.
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| |
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| Contributor(s) |
Drapkin R, Hooda J, Salomon MP, Hoon DB |
| Citation(s) |
30563893, 36509990 |
| |
| Submission date |
Nov 06, 2018 |
| Last update date |
Jan 06, 2023 |
| Contact name |
Dave S.B. Hoon |
| E-mail(s) |
[email protected]
|
| Organization name |
Saint John's Cancer Institute
|
| Department |
Translational Molecular Medicine
|
| Street address |
2200 Santa Monica Boulevard
|
| City |
Santa Monica |
| State/province |
CA |
| ZIP/Postal code |
90403 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE122238 |
Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer |
|
| Relations |
| BioProject |
PRJNA504052 |
| SRA |
SRP167977 |
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