|
| Status |
Public on Feb 08, 2019 |
| Title |
Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The histone demethylase LSD1 is a key chromatin regulator that plays a crucial role in development. It has been shown to act both as a co-repressor and a co-activator of genes expression and to affect the expression of many genes important for development. In Drosophila, dLsd1 is essential for oogenesis; however, our current knowledge of dLsd1 function is insufficient to explain its precise role in the ovary. To better define the role of dLsd1 in oogenesis, we performed genome-wide analysis of dLsd1 binding in the ovary by Chromatin Immunoprecipitation followed by sequencing (ChIP-Seq).
|
| |
|
| Overall design |
ChIP-seq profiles of dLsd1 binding in young wild type (w1118) ovaries were generated by deep sequencing in triplicate.
The ChIP-seq antibody was generated in the Dyson team in Boston [PMID 17462898]
|
| Web link |
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz1142/5651325#supplementary-data
|
| |
|
| Contributor(s) |
Di Stefano L |
| Citation(s) |
31799607 |
| |
| Submission date |
Feb 08, 2018 |
| Last update date |
Dec 17, 2019 |
| Contact name |
Luisa Di Stefano |
| E-mail(s) |
[email protected]
|
| Phone |
(33) 5 61 55 85 99
|
| Organization name |
Université Paul Sabatier - Toulouse III
|
| Lab |
Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération
|
| Street address |
LBCMCP - CNRS UMR5088 - IFR 109 Bât 4R3-B1 118 route de Narbonne
|
| City |
Toulouse Cedex 9 |
| State/province |
France |
| ZIP/Postal code |
31062 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL13304 |
Illumina HiSeq 2000 (Drosophila melanogaster) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA433482 |
| SRA |
SRP132465 |
Less...
More...