|
| Status |
Public on Mar 16, 2018 |
| Title |
Effects of 21 days of bedrest on human skeletal muscle gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression.
14 male subjects participated in normoxic bedrest (NBR) with muscle unloading, for 21 days, this is a substudy of tha PlanHab-study which apart from normoxic bedrest also involved hyboxic bedrest and hypoxic ambulation Throughout both bedrest interventions, each subject remained in a horizontal position at all times. He was allowed one pillow for the head and to occasionally lean on an elbow while eating or being transferred to a gurney. Muscular exercise was prohibited. During the HAMB confinement, each subject was allowed to move freely within the hypoxic area. To mimic a normal level of physical activity subjects performed 30 minutes of low-to-moderate-intensity exercise twice daily. Muscle samples from Vastus lateralis.
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| |
|
| Overall design |
Biospy material sufficient for anlaysis was available for 12x2 observations
|
| |
|
| Contributor(s) |
Rullman E |
| Citation(s) |
29995456 |
| |
| Submission date |
Oct 16, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Eric Rullman |
| E-mail(s) |
[email protected]
|
| Phone |
+46858586777
|
| Organization name |
Karolinska Institutet
|
| Department |
Laboratory Medicine
|
| Lab |
Clinical Physiology
|
| Street address |
C1:82 Karolinska University Hospital, Huddinge
|
| City |
Stockholm |
| ZIP/Postal code |
14186 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL17692 |
[HuGene-2_1-st] Affymetrix Human Gene 2.1 ST Array [transcript (gene) version] |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA414394 |
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